Pub. Date : 2013 Mar 25
PMID : 22982773
11 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
1 | A common mechanism for resistance to oxime reactivation of acetylcholinesterase inhibited by organophosphorus compounds. | Oximes | acetylcholinesterase (Cartwright blood group) | Homo sapiens |
2 | Administration of oxime therapy is currently the standard approach used to reverse the acute toxicity of organophosphorus (OP) compounds, which is usually attributed to OP inhibition of acetylcholinesterase (AChE). | Oximes | acetylcholinesterase (Cartwright blood group) | Homo sapiens |
3 | Administration of oxime therapy is currently the standard approach used to reverse the acute toxicity of organophosphorus (OP) compounds, which is usually attributed to OP inhibition of acetylcholinesterase (AChE). | Oximes | acetylcholinesterase (Cartwright blood group) | Homo sapiens |
4 | Rate constants for reactivation of OP-inhibited AChE by even the best oximes, such as HI-6 and obidoxime, can vary >100-fold between OP-AChE conjugates that are easily reactivated and those that are difficult to reactivate. | Oximes | acetylcholinesterase (Cartwright blood group) | Homo sapiens |
5 | Rate constants for reactivation of OP-inhibited AChE by even the best oximes, such as HI-6 and obidoxime, can vary >100-fold between OP-AChE conjugates that are easily reactivated and those that are difficult to reactivate. | Oximes | acetylcholinesterase (Cartwright blood group) | Homo sapiens |
6 | To gain a better understanding of this oxime specificity problem for future design of improved reactivators, we conducted a QSAR analysis for oxime reactivation of AChE inhibited by OP agents and their analogues. | Oximes | acetylcholinesterase (Cartwright blood group) | Homo sapiens |
7 | To gain a better understanding of this oxime specificity problem for future design of improved reactivators, we conducted a QSAR analysis for oxime reactivation of AChE inhibited by OP agents and their analogues. | Oximes | acetylcholinesterase (Cartwright blood group) | Homo sapiens |
8 | Our objective was to identify common mechanism(s) among OP-AChE conjugates of phosphates, phosphonates and phosphoramidates that result in resistance to oxime reactivation. | Oximes | acetylcholinesterase (Cartwright blood group) | Homo sapiens |
9 | Our evaluation of oxime reactivation of AChE inhibited by a sarin analogue, O-methyl isopropylphosphonofluoridate, or a cyclosarin analogue, O-methyl cyclohexylphosphonofluoridate, indicated that AChE inhibited by these analogues was at least 70-fold more difficult to reactivate than AChE inhibited by sarin or cyclosarin. | Oximes | acetylcholinesterase (Cartwright blood group) | Homo sapiens |
10 | Our evaluation of oxime reactivation of AChE inhibited by a sarin analogue, O-methyl isopropylphosphonofluoridate, or a cyclosarin analogue, O-methyl cyclohexylphosphonofluoridate, indicated that AChE inhibited by these analogues was at least 70-fold more difficult to reactivate than AChE inhibited by sarin or cyclosarin. | Oximes | acetylcholinesterase (Cartwright blood group) | Homo sapiens |
11 | Our evaluation of oxime reactivation of AChE inhibited by a sarin analogue, O-methyl isopropylphosphonofluoridate, or a cyclosarin analogue, O-methyl cyclohexylphosphonofluoridate, indicated that AChE inhibited by these analogues was at least 70-fold more difficult to reactivate than AChE inhibited by sarin or cyclosarin. | Oximes | acetylcholinesterase (Cartwright blood group) | Homo sapiens |