Title : Acquired resistance to cetuximab is mediated by increased PTEN instability and leads cross-resistance to gefitinib in HCC827 NSCLC cells.

Pub. Date : 2010 Oct 28

PMID : 20444542






2 Functional Relationships(s)
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Protein Name
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1 Inhibition of PI3K/Akt signaling pathway restored sensitivity to gefitinib in HCC827-CR cells. Gefitinib AKT serine/threonine kinase 1 Homo sapiens
2 Taken together, these data show that PTEN instability-mediated constitutive Akt activation is involved in acquired resistance mechanisms to cetuximab and also induces de novo resistance to gefitinib. Gefitinib AKT serine/threonine kinase 1 Homo sapiens