Title : Activation of the insulin-like growth factor-1 receptor induces resistance to epidermal growth factor receptor antagonism in head and neck squamous carcinoma cells.

Pub. Date : 2011 Nov

PMID : 21878657






1 Functional Relationships(s)
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1 In SCC-25 and Cal27 cells, gefitinib inhibited basal and EGF-stimulated EGFR, extracellular signal-regulated kinase (Erk), and Akt phosphorylation and reduced cell number. Gefitinib AKT serine/threonine kinase 1 Homo sapiens