2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one

AKT serine/threonine kinase 1 ; Homo sapiens







1802 Article(s)
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1 32762281 MiR-17-5p inhibits cerebral hypoxia/reoxygenationinjury by targeting PTEN through regulation of PI3K/AKT/mTOR signaling pathway. 2022 Feb 1
2 33997938 Curcumin Inhibits Viability of Clear Cell Renal Cell Carcinoma by Down-Regulating ADAMTS18 Gene Methylation though NF-κ B and AKT Signaling Pathway. 2022 May 1
3 34500338 Low-intensity pulsed ultrasound promotes angiogenesis via the AKT pathway and DNA methylation in human umbilical vein endothelial cells. 2022 Jan 2
4 34678088 PDGFRβ modulates aerobic glycolysis in osteosarcoma HOS cells via the PI3K/AKT/mTOR/c-Myc pathway. 2022 Feb 1
5 34813998 Drug connectivity mapping and functional analysis reveal therapeutic small molecules that differentially modulate myelination. 2022 Jan 1
6 34846946 SET8, a novel regulator to ameliorate vascular calcification via activating PI3K/Akt mediated anti-apoptotic effects. 2022 Apr 2
7 34875308 Reconstituted HDL-apoE3 promotes endothelial cell migration through ID1 and its downstream kinases ERK1/2, AKT and p38 MAPK. 2022 Feb 1
8 34913077 AIM2 inhibits the proliferation, invasion and migration, and promotes the apoptosis of osteosarcoma cells by inactivating the PI3K/AKT/mTOR signaling pathway. 2022 Feb 1
9 34935059 Berberine enhances gemcitabine‑induced cytotoxicity in bladder cancer by downregulating Rad51 expression through inactivating the PI3K/Akt pathway. 2022 Feb 1
10 34949154 24-Dehydrocholesterol Reductase alleviates oxidative damage-induced apoptosis in alveolar epithelial cells via regulating Phosphatidylinositol-3-Kinase/Protein Kinase B activation. 2022 Jan 1
11 34958867 Therapeutic potential of the PI3K inhibitor LY294002 and PARP inhibitor Talazoparib combination in BRCA-deficient triple negative breast cancer cells. 2022 Mar 1
12 34974760 Malignant growth of arsenic-transformed cells depends on activated Akt induced by reactive oxygen species. 2022 Jan 2 2
13 35001339 VLCAD inhibits the proliferation and invasion of hepatocellular cancer cells through regulating PI3K/AKT axis. 2022 May 1
14 35007896 Ski regulates proliferation and migration of reactive astrocytes induced by lipopolysaccharide (LPS) through PI3K/Akt pathway. 2022 Mar 15 1
15 35129008 Endogenous Ca2+ release was involved in 50-Hz MF-induced proliferation via Akt-SK1 signal cascade in human amniotic epithelial cells. 2022 Apr 3 1
16 35149293 IL-25 improves diabetic wound healing through stimulating M2 macrophage polarization and fibroblast activation. 2022 May 1
17 35164673 Programmed death-ligand 1 signaling and expression are reversible by lycopene via PI3K/AKT and Raf/MEK/ERK pathways in tongue squamous cell carcinoma. 2022 Feb 14 1
18 35176991 Fangchinoline inhibited proliferation of neoplastic B-lymphoid cells and alleviated Sjögren's syndrome-like responses in NOD/Ltj mice via the Akt/mTOR pathway. 2022 Feb 17 1
19 35218109 LncRNA KCNQ1OT1-mediated cervical cancer progression by sponging miR-1270 as a ceRNA of LOXL2 through PI3k/Akt pathway. 2022 Apr 4
20 35218761 Semaphorin 7A Accelerates the Inflammatory Osteolysis of Periapical Lesions. 2022 May 2
21 35222803 Protection of Human Lens Epithelial Cells from Oxidative Stress Damage and Cell Apoptosis by KGF-2 through the Akt/Nrf2/HO-1 Pathway. 2022 2
22 35242234 PI3K/Akt/YAP signaling promotes migration and invasion of DLD-1 colorectal cancer cells. 2022 Apr 1
23 35255737 MiR-379-5p Promotes Chondrocyte Proliferation via Inhibition of PI3K/Akt Pathway by Targeting YBX1 in Osteoarthritis. 2022 Jan-Mar 2
24 35277194 G6PC indicated poor prognosis in cervical cancer and promoted cervical carcinogenesis in vitro and in vivo. 2022 Mar 11 1
25 35333664 Kukoamine A attenuates lipopolysaccharide-induced apoptosis, extracellular matrix degradation, and inflammation in nucleus pulposus cells by activating the P13K/Akt pathway. 2022 Apr 1
26 35387349 Metformin Promotes Differentiation and Attenuates H2O2-Induced Oxidative Damage of Osteoblasts via the PI3K/AKT/Nrf2/HO-1 Pathway. 2022 1
27 35413475 Kaposi's sarcoma-associated herpes virus-derived microRNA K12-1 over-activates the PI3K/Akt pathway to facilitate cancer progression in HIV-related gastrointestinal Kaposi's sarcoma. 2022 Jun 1
28 35461041 Long noncoding RNA KB-1980E6.3 promotes breast cancer progression through the PI3K/AKT signalling pathway. 2022 Jun 1
29 35478128 Analysis of Spontaneous and Induced Osteogenic Differentiation in 3D-micromasses of Human Multipotent Stem Cells. 2022 May-Jun 1
30 35514261 Evidence for a PI3-kinase independent pathway in the regulation of Rap1b activation downstream of the P2Y12 receptor in platelets. 2022 May 6 1
31 35602302 Hax-1 Regulates Radiation-Induced Mitochondrial-Dependent Apoptosis of Uveal Melanoma Cells through PI3K/AKT/eNOS Pathway. 2022 1
32 35605918 A diarylheptanoid compound from Alpinia officinarum Hance ameliorates high glucose-induced insulin resistance by regulating PI3K/AKT-Nrf2-GSK3β signaling pathways in HepG2 cells. 2022 Sep 15 1
33 35607451 Melatonin increases growth properties in human dermal papilla spheroids by activating AKT/GSK3β/β-Catenin signaling pathway. 2022 1
34 35623361 Silicon-substituted calcium phosphate promotes osteogenic-angiogenic coupling by activating the TLR4/PI3K/AKT signaling axis. 2022 May 27 1
35 31462074 The PI3K-Akt-HIF-1α Pathway Reducing Nasal Airway Inflammation and Remodeling in Nasal Polyposis. 2021 Jan 1
36 32393798 An optically active isochroman-2H-chromene conjugate potently suppresses neuronal oxidative injuries associated with the PI3K/Akt and MAPK signaling pathways. 2021 Jan 1
37 32811251 Protease-activated receptor 4 causes Akt phosphorylation independently of PI3 kinase pathways. 2021 Aug 18 1
38 32900356 Quercetin Inhibits AQP1 Translocation in High-Glucose-Cultured SRA01/04 Cells Through PI3K/Akt/mTOR Pathway. 2021 Oct 25 1
39 33001018 The AMPAR Antagonist Perampanel Regulates Neuronal Necroptosis via Akt/GSK3β Signaling After Acute Traumatic Injury in Cortical Neuron. 2021 Oct 26 1
40 33037575 Folic Acid Deficiency Enhances the Tyr705 and Ser727 Phosphorylation of Mitochondrial STAT3 in In Vivo and In Vitro Models of Ischemic Stroke. 2021 Oct 1
41 33212374 Boesenbergia rotunda extract accelerates human keratinocyte proliferation through activating ERK1/2 and PI3K/Akt kinases. 2021 Jan 1
42 33217443 Human RECQL5 promotes metastasis and resistance to cisplatin in non-small cell lung cancer. 2021 Jan 15 1
43 33226571 Melatonin upregulates DNA-PKcs to suppress apoptosis of human umbilical vein endothelial cells via inhibiting miR-101 under H2O2-induced oxidative stress. 2021 Feb 1
44 33227289 Coptisine induces autophagic cell death through down-regulation of PI3K/Akt/mTOR signaling pathway and up-regulation of ROS-mediated mitochondrial dysfunction in hepatocellular carcinoma Hep3B cells. 2021 Jan 15 1
45 33241954 CXCL6 regulates cell permeability, proliferation, and apoptosis after ischemia-reperfusion injury by modulating Sirt3 expression via AKT/FOXO3a activation. 2021 Jan 2 2
46 33258087 Mechanism of Human Umbilical Cord Mesenchymal Stem Cells Derived-Extracellular Vesicle in Cerebral Ischemia-Reperfusion Injury. 2021 Mar 1
47 33269749 Apelin-13 inhibits apoptosis and excessive autophagy in cerebral ischemia/reperfusion injury. 2021 Jun 1
48 33290316 A PI3K inhibitor-induced growth inhibition of cancer cells is linked to MEK-ERK pathway. 2021 Jun 1 1
49 33391425 HnRNP-F promotes the proliferation of bladder cancer cells mediated by PI3K/AKT/FOXO1. 2021 1
50 33404163 Roles of metformin-mediated girdin expression in metastasis of epithelial ovarian cancer. 2021 May 1