Title : MiR-17-5p inhibits cerebral hypoxia/reoxygenationinjury by targeting PTEN through regulation of PI3K/AKT/mTOR signaling pathway.

Pub. Date : 2022 Feb

PMID : 32762281






1 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 Treatment of PI3K inhibitor LY294002 significantly increased the apoptosis rate of HBMVECs, and this effect was significantly reversed by transfection of miR-17-5p mimics, while further dramatically enhanced by overexpression of PTEN.Conclusion: MiR-17-5p could amelioratecerebral I/R injury-induced cell apoptosis by directly targeting PTEN and regulation of PI3K/AKT/mTOR signaling. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one AKT serine/threonine kinase 1 Homo sapiens