Title : A diarylheptanoid compound from Alpinia officinarum Hance ameliorates high glucose-induced insulin resistance by regulating PI3K/AKT-Nrf2-GSK3β signaling pathways in HepG2 cells.

Pub. Date : 2022 Sep 15

PMID : 35605918






1 Functional Relationships(s)
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1 The mechanism underlying the effect of DPH5 in alleviating IR was related to the PI3K/AKT- and Nrf2/HO-1-mediated regulation of the GSK3beta signaling pathway, and the results were further confirmed using the specific inhibitors LY294002 and ML385. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one AKT serine/threonine kinase 1 Homo sapiens