Aflatoxins

tumor protein p53 ; Homo sapiens







69 Article(s)
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1 32382660 Analysis of TP53 aflatoxin signature mutation in hepatocellular carcinomas from Guatemala: A cross-sectional study (2016-2017). 2020 Jun 1
2 33053575 Metabolic Syndrome Instead of Aflatoxin-Related TP53 R249S Mutation as a Hepatocellular Carcinoma Risk Factor. 2020 May 7 2
3 29089331 Prevalence of Aflatoxin-Associated TP53R249S Mutation in Hepatocellular Carcinoma in Hispanics in South Texas. 2018 Feb 1
4 29749584 Droplet digital PCR detects high rate of TP53 R249S mutants in cell-free DNA of middle African patients with hepatocellular carcinoma. 2018 Aug 1
5 28428144 Association of Aflatoxin and Gallbladder Cancer. 2017 Aug 1
6 25886382 Molecular characteristics of Hepatitis B and chronic liver disease in a cohort of HB carriers from Bamako, Mali. 2015 Apr 11 2
7 24657665 The association between exposure to aflatoxin, mutation in TP53, infection with hepatitis B virus, and occurrence of liver disease in a selected population in Hyderabad, India. 2014 May 15 1
8 25404244 p53 in liver pathologies-taking the good with the bad. 2014 Dec 1
9 23200676 Association between HBX status, aflatoxin-induced R249S TP53 mutation and risk of hepatocellular carcinoma in a case-control study from Thailand. 2013 Apr 30 2
10 23649769 Hepatocellular carcinoma and liver cirrhosis TP53 mutation analysis reflects a moderate dietary exposure to aflatoxins in EspĂ­rito Santo State, Brazil. 2013 Aug 4
11 23836507 Association between TP53 R249S mutation and polymorphisms in TP53 intron 1 in hepatocellular carcinoma. 2013 Oct 2
12 24460352 Prevalence of aflatoxin induced p53 mutation at codon 249 (R249s) in hepatocellular carcinoma patients with and without hepatitis B surface antigen (HBsAg). 2013 2
13 22675488 Aflatoxin-induced TP53 R249S mutation in hepatocellular carcinoma in Thailand: association with tumors developing in the absence of liver cirrhosis. 2012 2
14 21382167 Aflatoxin genotoxicity is associated with a defective DNA damage response bypassing p53 activation. 2011 Apr 2
15 21760996 Mutations in TP53 and CTNNB1 in Relation to Hepatitis B and C Infections in Hepatocellular Carcinomas from Thailand. 2011 2
16 20017137 Cooperation of tumor-derived HBx mutants and p53-249(ser) mutant in regulating cell proliferation, anchorage-independent growth and aneuploidy in a telomerase-immortalized normal human hepatocyte-derived cell line. 2010 Sep 1 1
17 20306157 The prevalence of the mutation in codon 249 of the P53 gene in patients with hepatocellular carcinoma (HCC) in Turkey. 2010 Sep 1
18 19345001 A model of interaction: aflatoxins and hepatitis viruses in liver cancer aetiology and prevention. 2009 Dec 1 1
19 19366907 TP53 R249S mutations, exposure to aflatoxin, and occurrence of hepatocellular carcinoma in a cohort of chronic hepatitis B virus carriers from Qidong, China. 2009 May 1
20 19376640 The aflatoxin-induced TP53 mutation at codon 249 (R249S): biomarker of exposure, early detection and target for therapy. 2009 Dec 1 1
21 19558663 249 TP53 mutation has high prevalence and is correlated with larger and poorly differentiated HCC in Brazilian patients. 2009 Jun 26 1
22 17113242 Novel adenine adducts, N7-guanine-AFB1 adducts, and p53 mutations in patients with schistosomiasis and aflatoxin exposure. 2006 1
23 16103461 Absence of TP53 codon 249 mutations in young Guinean children with high aflatoxin exposure. 2005 Aug 3
24 15095302 Ser-249TP53 mutation in tumour and plasma DNA of hepatocellular carcinoma patients from a high incidence area in the Gambia, West Africa. 2004 Jun 20 1
25 12679912 Codon 249 mutation in exon 7 of p53 gene in plasma DNA: maybe a new early diagnostic marker of hepatocellular carcinoma in Qidong risk area, China. 2003 Apr 1
26 12714181 On the origin of G --> T transversions in lung cancer. 2003 May 15 1
27 12395332 Dominant role of hepatitis B virus and cofactor role of aflatoxin in hepatocarcinogenesis in Qidong, China. 2002 Nov 1
28 12435844 The toxicology of aflatoxins as a basis for public health decisions. 2002 Nov 2
29 11220661 Exposure biomarkers in chemoprevention studies of liver cancer. 2001 1
30 11401911 Hepatitis B, aflatoxin B(1), and p53 codon 249 mutation in hepatocellular carcinomas from Guangxi, People's Republic of China, and a meta-analysis of existing studies. 2001 Jun 2
31 11685745 Molecular mechanisms underlying the development of hepatocellular carcinoma. 2001 Oct 1
32 14510167 P53 codon 249 mutation in hepatocellular carcinomas from Nigeria. 2001 Mar-Jun 1
33 10958934 A comprehensive karyotypic analysis on a newly developed hepatocellular carcinoma cell line, HKCI-1, by spectral karyotyping and comparative genomic hybridization. 2000 Aug 1
34 10960967 [Molecular aspects of hepatocellular carcinoma]. 2000 1
35 10064859 DNA damage by mycotoxins. 1999 Mar 8 2
36 10374839 Mutations associated with in vivo aflatoxin B1-induced carcinogenesis need not be present in the in vitro transformations by this toxin. 1999 Apr 1 1
37 10389978 Genetic alterations in hepatocellular carcinomas: association between loss of chromosome 4q and p53 gene mutations. 1999 Apr 1
38 11104412 Aflatoxin, Tobacco, Ammonia and the p53 Tumor-Suppressor Gene: Cancer's Missing Link? 1999 Aug 30 2
39 9163674 In vitro activation of the human Harvey-ras proto-oncogene by aflatoxin B1. 1997 May 1
40 9189703 Hepatocellular carcinoma p53 G > T transversions at codon 249: the fingerprint of aflatoxin exposure? 1997 Apr 5
41 9414172 Hepatocellular carcinoma: from gene to public health. 1997 Dec 17 1
42 8640905 An aflatoxin-associated mutational hotspot at codon 249 in the p53 tumor suppressor gene occurs in hepatocellular carcinomas from Mexico. 1996 May 1
43 8921985 Mutations of the p53 tumor suppressor gene and ras oncogenes in aflatoxin hepatocarcinogenesis. 1996 Oct 1
44 9006107 Absence of mutations in the p53 tumor suppressor gene in woodchuck hepatocellular carcinomas associated with hepadnavirus infection and intake of aflatoxin B1. 1996 Dec 2
45 7557882 Introduction of a murine p53 mutation corresponding to human codon 249 into a murine hepatocyte cell line results in growth advantage, but not in transformation. 1995 Oct 1
46 7605578 Characterization of a murine p53ser246 mutant equivalent to the human p53ser249 associated with hepatocellular carcinoma and aflatoxin exposure. 1995 Jun 2
47 7664937 Recent aflatoxin exposure and mutation at codon 249 of the human p53 gene: lack of association. 1995 May-Jun 2
48 7757303 Characterization of a new human glioblastoma cell line that expresses mutant p53 and lacks activation of the PDGF pathway. 1995 Mar 1
49 8541111 p53 in malignant and benign liver lesions. 1995 Oct 1
50 7923176 State of the p53 gene in hepatocellular carcinomas of ground squirrels and woodchucks with past and ongoing infection with hepadnaviruses. 1994 Oct 15 2