PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 32382660-0 2020 Analysis of TP53 aflatoxin signature mutation in hepatocellular carcinomas from Guatemala: A cross-sectional study (2016-2017). Aflatoxins 17-26 tumor protein p53 Homo sapiens 12-16 29089331-0 2018 Prevalence of Aflatoxin-Associated TP53R249S Mutation in Hepatocellular Carcinoma in Hispanics in South Texas. Aflatoxins 14-23 tumor protein p53 Homo sapiens 35-39 33053575-0 2020 Metabolic Syndrome Instead of Aflatoxin-Related TP53 R249S Mutation as a Hepatocellular Carcinoma Risk Factor. Aflatoxins 30-39 tumor protein p53 Homo sapiens 48-52 33053575-3 2020 OBJECTIVE: The objective of the study was to explore if HCCs carry the TP53 R249S mutation that has linked them to aflatoxin exposure and describe the associated risk factors. Aflatoxins 115-124 tumor protein p53 Homo sapiens 71-75 29749584-3 2018 The role of aflatoxin in HCC from a given population is commonly estimated through the prevalence of R249S mutation of TP53, a hallmark for previous exposure to the mycotoxin. Aflatoxins 12-21 tumor protein p53 Homo sapiens 119-123 25886382-6 2015 A mutation of TP53 at codon 249 (R249S), specific for exposure to aflatoxin, was detected in cell-free DNA extracted from plasma. Aflatoxins 66-75 tumor protein p53 Homo sapiens 14-18 28428144-5 2017 In 54 patients with gallbladder cancer, tumor tissue was examined for the R249S mutation in TP53, associated with aflatoxin exposure, through targeted sequencing. Aflatoxins 114-123 tumor protein p53 Homo sapiens 92-96 25886382-14 2015 About 1/3 of carriers have moderate to severe liver fibrosis and 60% have detectable aflatoxin-related TP53 R249S mutation. Aflatoxins 85-94 tumor protein p53 Homo sapiens 103-107 24657665-3 2014 The G to T transversion at the third position of codon 249 (AGG) of the TP53 gene, substituting arginine to serine, is the most common aflatoxin-induced mutation linked to HCC. Aflatoxins 135-144 tumor protein p53 Homo sapiens 72-76 25404244-8 2014 Furthermore, the accumulations of carcinogens such as aflatoxin were shown to yield an oncogenic mutated p53 protein. Aflatoxins 54-63 tumor protein p53 Homo sapiens 105-108 23836507-5 2013 We have analyzed the associations between 19 SNPs spanning the TP53 locus and a single specific aflatoxin-induced TP53 mutation (R249S) in 85 in hepatocellular carcinoma cases and 132 controls from Thailand. Aflatoxins 96-105 tumor protein p53 Homo sapiens 63-67 23836507-5 2013 We have analyzed the associations between 19 SNPs spanning the TP53 locus and a single specific aflatoxin-induced TP53 mutation (R249S) in 85 in hepatocellular carcinoma cases and 132 controls from Thailand. Aflatoxins 96-105 tumor protein p53 Homo sapiens 114-118 23200676-0 2013 Association between HBX status, aflatoxin-induced R249S TP53 mutation and risk of hepatocellular carcinoma in a case-control study from Thailand. Aflatoxins 32-41 tumor protein p53 Homo sapiens 56-60 23649769-0 2013 Hepatocellular carcinoma and liver cirrhosis TP53 mutation analysis reflects a moderate dietary exposure to aflatoxins in Espirito Santo State, Brazil. Aflatoxins 108-118 tumor protein p53 Homo sapiens 45-49 23649769-1 2013 The close relationship between aflatoxins and 249ser TP53 gene mutation (AGG to AGT, Arg to Ser) in hepatocellular carcinoma (HCC) makes this mutation an indirect indicator of dietary contamination with this toxin. Aflatoxins 31-41 tumor protein p53 Homo sapiens 53-57 23649769-9 2013 TP53 exon 7 mutations, which are related to aflatoxins exposure, were found at 14.6% (249ser), 7.3% (250leu) and 2.4% (250ser) in 41 cases of HCC and 1.4% in 74 liver cirrhosis (without HCC) cases, suggesting a moderate dietary exposure to aflatoxins in the Espirito Santo State, Brazil. Aflatoxins 44-54 tumor protein p53 Homo sapiens 0-4 23649769-9 2013 TP53 exon 7 mutations, which are related to aflatoxins exposure, were found at 14.6% (249ser), 7.3% (250leu) and 2.4% (250ser) in 41 cases of HCC and 1.4% in 74 liver cirrhosis (without HCC) cases, suggesting a moderate dietary exposure to aflatoxins in the Espirito Santo State, Brazil. Aflatoxins 240-250 tumor protein p53 Homo sapiens 0-4 23200676-1 2013 Hepatocellular carcinoma (HCC) is associated with hepatitis B virus (HBV) chronicity and dietary exposure to aflatoxin, a mutagen targeting codon 249 of tumor suppressor TP53 (R249S mutation). Aflatoxins 109-118 tumor protein p53 Homo sapiens 170-174 22675488-0 2012 Aflatoxin-induced TP53 R249S mutation in hepatocellular carcinoma in Thailand: association with tumors developing in the absence of liver cirrhosis. Aflatoxins 0-9 tumor protein p53 Homo sapiens 18-22 24460352-0 2013 Prevalence of aflatoxin induced p53 mutation at codon 249 (R249s) in hepatocellular carcinoma patients with and without hepatitis B surface antigen (HBsAg). Aflatoxins 14-23 tumor protein p53 Homo sapiens 32-35 24460352-14 2013 CONCLUSIONS: Our study shows moderate prevalence of aflatoxin B1-related p53 mutation (R249S) in HCC with or without HBsAg. Aflatoxins 52-61 tumor protein p53 Homo sapiens 73-76 22675488-3 2012 Most HCC are associated with chronic infection by Hepatitis B Virus while a G T mutation at codon 249 of the TP53 gene, R249S, specific for exposure to aflatoxin, is detected in tumors for up to 30% of cases. Aflatoxins 154-163 tumor protein p53 Homo sapiens 111-115 19558663-1 2009 BACKGROUND: Ser-249 TP53 mutation (249(Ser)) is a molecular evidence for aflatoxin-related carcinogenesis in Hepatocellular Carcinoma (HCC) and it is frequent in some African and Asian regions, but it is unusual in Western countries. Aflatoxins 73-82 tumor protein p53 Homo sapiens 20-24 20306157-7 2010 In conclusion, although codon 249 mutation of p53 gene has been found very rare but it exists showing the effect of aflatoxins in HCC patients in Turkey. Aflatoxins 116-126 tumor protein p53 Homo sapiens 46-49 21382167-0 2011 Aflatoxin genotoxicity is associated with a defective DNA damage response bypassing p53 activation. Aflatoxins 0-9 tumor protein p53 Homo sapiens 84-87 21382167-2 2011 Aflatoxins, which may play a causative role in 5-28% of HCCs worldwide, are activated in liver cells and induce principally G T mutations, including the TP53 codon 249(G T) hotspot mutation. Aflatoxins 0-10 tumor protein p53 Homo sapiens 153-157 21760996-4 2011 TP53 and CTNNB1 mutations were not mutually exclusive, and most of TP53 mutations were R249S, suggesting a significant impact of aflatoxin-induced mutagenesis in HCC development. Aflatoxins 129-138 tumor protein p53 Homo sapiens 0-4 21760996-4 2011 TP53 and CTNNB1 mutations were not mutually exclusive, and most of TP53 mutations were R249S, suggesting a significant impact of aflatoxin-induced mutagenesis in HCC development. Aflatoxins 129-138 tumor protein p53 Homo sapiens 67-71 20017137-2 2010 Convincing epidemiological and experimental evidence also links HCC to aflatoxin, a naturally occurring mycotoxin that produces a signature p53-249(ser) mutation. Aflatoxins 71-80 tumor protein p53 Homo sapiens 140-143 19345001-3 2009 Aflatoxin B1, the most commonly occurring and potent of the aflatoxins is associated with a specific AGG to AGT transversion mutation at codon 249 of the p53 gene in human HCC, providing mechanistic support to a causal link between exposure and disease. Aflatoxins 60-70 tumor protein p53 Homo sapiens 154-157 19376640-0 2009 The aflatoxin-induced TP53 mutation at codon 249 (R249S): biomarker of exposure, early detection and target for therapy. Aflatoxins 4-13 tumor protein p53 Homo sapiens 22-26 19366907-2 2009 A single base substitution at the third nucleotide of codon 249 of TP53 (R249S) is common in HCC in these regions and has been associated with aflatoxin-DNA adducts. Aflatoxins 143-152 tumor protein p53 Homo sapiens 67-71 17113242-0 2006 Novel adenine adducts, N7-guanine-AFB1 adducts, and p53 mutations in patients with schistosomiasis and aflatoxin exposure. Aflatoxins 103-112 tumor protein p53 Homo sapiens 52-55 16103461-0 2005 Absence of TP53 codon 249 mutations in young Guinean children with high aflatoxin exposure. Aflatoxins 72-81 tumor protein p53 Homo sapiens 11-15 16103461-3 2005 A mutation in the TP53 tumor suppressor gene at codon 249 (TP53 Ser249 mutation) has been reported previously for hepatocellular carcinoma tumors and matched plasma DNA samples in individuals from areas with high aflatoxin exposure. Aflatoxins 213-222 tumor protein p53 Homo sapiens 18-22 16103461-3 2005 A mutation in the TP53 tumor suppressor gene at codon 249 (TP53 Ser249 mutation) has been reported previously for hepatocellular carcinoma tumors and matched plasma DNA samples in individuals from areas with high aflatoxin exposure. Aflatoxins 213-222 tumor protein p53 Homo sapiens 59-63 15095302-2 2004 A selective mutation in TP53 (AGG-->AGT at codon 249, Arg-->Ser) has been identified as a hotspot in HCCs from such areas, reflecting DNA damage caused by aflatoxin metabolites. Aflatoxins 161-170 tumor protein p53 Homo sapiens 24-28 11401911-3 2001 A G to T transversion at codon 249 of the p53 gene (249(ser)) is commonly found in HCCs from patients in regions with dietary aflatoxin exposure. Aflatoxins 126-135 tumor protein p53 Homo sapiens 42-45 12714181-1 2003 G-->T transversions in the TP53 gene are more common in lung cancers from smokers than in any other cancer except for hepatocellular carcinomas linked to aflatoxin. Aflatoxins 157-166 tumor protein p53 Homo sapiens 30-34 11685745-5 2001 Exposure to aflatoxin is associated with a specific mutation in the tumor-suppressor gene p53. Aflatoxins 12-21 tumor protein p53 Homo sapiens 90-93 12679912-1 2003 AIM: One of the characteristics of hepatocellular carcinoma (HCC) in Qidong area is the selective mutation resulting in a serine substitution at codon 249 of the p53 gene (1, 20), and it has been identified as a "hotspot" mutation in heptocellular carcinomas occurring in populations exposed to aflatoxin and with high prevalence of hepatitis B virus carriers (2,3,9, 10,16,24). Aflatoxins 295-304 tumor protein p53 Homo sapiens 162-165 12395332-7 2002 A similar relative risk was found using 249ser-p53 mutation as a marker for aflatoxin exposure. Aflatoxins 76-85 tumor protein p53 Homo sapiens 47-50 12435844-3 2002 The improvements in exposure assessment and their application in prospective epidemiological studies and the demonstration of a specific mutation in the TP53 gene in hepatocellular carcinomas from areas of high aflatoxin exposure have contributed significantly to the classification of aflatoxins as human carcinogens. Aflatoxins 211-220 tumor protein p53 Homo sapiens 153-157 12435844-3 2002 The improvements in exposure assessment and their application in prospective epidemiological studies and the demonstration of a specific mutation in the TP53 gene in hepatocellular carcinomas from areas of high aflatoxin exposure have contributed significantly to the classification of aflatoxins as human carcinogens. Aflatoxins 286-296 tumor protein p53 Homo sapiens 153-157 11401911-9 2001 Second, we present a meta-analysis, using our results along with those from 48 published studies, that examines the interrelationships among aflatoxin exposure, HBV infection, and p53 mutations in HCCs. Aflatoxins 141-150 tumor protein p53 Homo sapiens 180-183 14510167-1 2001 Mutations of p53 tumour suppressor gene often occur in hepatocellular carcinoma and, in particular, codon 249 hot-spot mutation is displayed by hepatocellular carcinomas occurring in hepatitis B virus-endemic areas with high dietary aflatoxin intake. Aflatoxins 233-242 tumor protein p53 Homo sapiens 13-16 10960967-6 2000 Finally, aflatoxins have been shown to induce specific mutations of the p53 tumor suppressor gene, thus pointing to the contribution of environmental factors to tumor development at the molecular level. Aflatoxins 9-19 tumor protein p53 Homo sapiens 72-75 11220661-9 2001 Aflatoxin-related mutations at codon 249 of the p53 gene in plasma may be more relevant in this regard but their application requires further understanding of the temporal appearance of this biomarker in relation to the natural history of the disease. Aflatoxins 0-9 tumor protein p53 Homo sapiens 48-51 10958934-13 2000 TP53 mutational analysis showed that both HKCI-1 and the primary tumor had the aflatoxin-associated mutation in codon 249 and an additional TP53 polymorphism in codon 72. Aflatoxins 79-88 tumor protein p53 Homo sapiens 0-4 10389978-5 1999 All seven HCCs with a p53 mutation from Qidong and three of five from Shanghai had the aflatoxin-associated point mutation with a G to T transversion at codon 249, position 3. Aflatoxins 87-96 tumor protein p53 Homo sapiens 22-25 11104412-0 1999 Aflatoxin, Tobacco, Ammonia and the p53 Tumor-Suppressor Gene: Cancer"s Missing Link? Aflatoxins 0-9 tumor protein p53 Homo sapiens 36-39 11104412-4 1999 Tobacco-related cancers, including those associated with ETS, often show the same p53 mutations associated with aflatoxin exposure. Aflatoxins 112-121 tumor protein p53 Homo sapiens 82-85 10374839-2 1999 An association has been detected between human exposure to aflatoxins, and mutations in the third base of codon 249 of the p53 gene in hepatomas. Aflatoxins 59-69 tumor protein p53 Homo sapiens 123-126 10064859-13 1999 More strikingly, the relationship between aflatoxin exposure and development of human hepatocellular carcinoma (HHC) was demonstrated by the studies on the p53 tumor suppressor gene. Aflatoxins 42-51 tumor protein p53 Homo sapiens 156-159 10064859-14 1999 High frequency of p53 mutations (G-->T transversion at codon 249) was found to occur in HHC collected from populations exposed to high levels of dietary aflatoxin in China and Southern Africa. Aflatoxins 156-165 tumor protein p53 Homo sapiens 18-21 9163674-9 1997 It appears that, in contrast to the frequently reported G-->T transversions in codon 249 of the p53 gene in primary hepatomas in aflatoxin-exposed humans, the failure to detect Ha-ras mutations in these tumours is not due to an inability of aflatoxin B1 to activate this proto-oncogene. Aflatoxins 132-141 tumor protein p53 Homo sapiens 99-102 9414172-4 1997 The recently developed individual biochemical and molecular markers of aflatoxin exposure, i.e., aflatoxin-albumin adducts in blood and a specific GC to TA transversion mutation in codon 249 of the p53 gene (249ser p53 mutation) in hepatocellular carcinomas, permit a better quantitative estimation of aflatoxin exposure in different populations of the world. Aflatoxins 71-80 tumor protein p53 Homo sapiens 198-201 7605578-0 1995 Characterization of a murine p53ser246 mutant equivalent to the human p53ser249 associated with hepatocellular carcinoma and aflatoxin exposure. Aflatoxins 125-134 tumor protein p53 Homo sapiens 70-73 9189703-0 1997 Hepatocellular carcinoma p53 G > T transversions at codon 249: the fingerprint of aflatoxin exposure? Aflatoxins 85-94 tumor protein p53 Homo sapiens 25-28 9189703-7 1997 Patients from areas with high aflatoxin levels were more likely to have p53 mutations than were patients from areas with low aflatoxin levels. Aflatoxins 30-39 tumor protein p53 Homo sapiens 72-75 9189703-8 1997 In the group with p53 mutations, patients from areas with high aflatoxin levels had higher proportions of mutations with codon 249 G > T transversions. Aflatoxins 63-72 tumor protein p53 Homo sapiens 18-21 9189703-10 1997 Aflatoxin may increase the proportion of p53 mutations by causing a single mutation, the codon 249 G > T transversion, thus explaining some of the excess liver cancer associated with aflatoxin exposure. Aflatoxins 0-9 tumor protein p53 Homo sapiens 41-44 9189703-10 1997 Aflatoxin may increase the proportion of p53 mutations by causing a single mutation, the codon 249 G > T transversion, thus explaining some of the excess liver cancer associated with aflatoxin exposure. Aflatoxins 186-195 tumor protein p53 Homo sapiens 41-44 9006107-2 1996 A high rate of mutations in the p53 tumor suppressor gene in hepatocellular carcinomas of predominantly hepatitis B virus (HBV) carrier patients has been recently related to dietary aflatoxin. Aflatoxins 182-191 tumor protein p53 Homo sapiens 32-35 9006107-9 1996 Overall, our findings indicate that in woodchucks and in ground squirrels exposure to aflatoxin may affect the development of p53 mutations less than in humans. Aflatoxins 86-95 tumor protein p53 Homo sapiens 126-129 8921985-5 1996 The most significant finding is that more than 50% of HCC patients from high aflatoxin exposure areas such as southern Africa and Qidong, China harboured a codon 249 G to T transversion in the p53 tumor suppressor gene, which is found to be consistent with the mutagenic specificity of AFB1 observed in vitro. Aflatoxins 77-86 tumor protein p53 Homo sapiens 193-196 8640905-0 1996 An aflatoxin-associated mutational hotspot at codon 249 in the p53 tumor suppressor gene occurs in hepatocellular carcinomas from Mexico. Aflatoxins 3-12 tumor protein p53 Homo sapiens 63-66 8541111-4 1995 The detection of p53 in a relatively high percentage of the HCC cases in Hungary, a country in which aflatoxin contamination of the diet is rare, suggests that factors other than aflatoxin led to the accumulation or overexpression of p53 in these patients. Aflatoxins 101-110 tumor protein p53 Homo sapiens 17-20 7557882-1 1995 The p53 gene is frequently mutated in human tumors; in hepatocellular carcinomas, there is a high frequency of a specific mutation at codon 249 in regions with significant aflatoxin exposure. Aflatoxins 172-181 tumor protein p53 Homo sapiens 4-7 7605578-1 1995 A mutation in the tumor suppressor p53 gene resulting in an Arg-->Ser substitution in position 249 is found frequently in human hepatocellular carcinomas associated with hepatitis B infection and with aflatoxin exposure. Aflatoxins 204-213 tumor protein p53 Homo sapiens 35-38 7955067-8 1994 To demonstrate the program, the mutational spectra of single base substitutions in the p53 gene are compared in (i) bladder cancers from smokers and non-smokers, (ii) small-cell lung cancers, non-small-cell lung cancers and colon cancers and (iii) hepatocellular carcinomas from high- and low-aflatoxin exposure groups. Aflatoxins 293-302 tumor protein p53 Homo sapiens 87-90 7664937-0 1995 Recent aflatoxin exposure and mutation at codon 249 of the human p53 gene: lack of association. Aflatoxins 7-16 tumor protein p53 Homo sapiens 65-68 7664937-1 1995 Experiments were done to show whether a G to T mis-sense mutation at the third base of codon 249 of the p53 tumour suppressor gene is a "hot spot" of aflatoxin attack as suggested by the results of epidemiological studies. Aflatoxins 150-159 tumor protein p53 Homo sapiens 104-107 7923176-2 1994 Recently, a broad range of mutations in the p53 tumor suppressor gene has been reported in human HCCs, predominantly from hepatitis B virus carriers in areas with either high or low levels of exposure to dietary aflatoxin. Aflatoxins 212-221 tumor protein p53 Homo sapiens 44-47 7923176-12 1994 In view of the considerably lower apparent rate of mutations in comparison to human HCCs, we suggest a less important role for aflatoxin in the induction of p53 mutations in HCCs of ground squirrels. Aflatoxins 127-136 tumor protein p53 Homo sapiens 157-160 7757303-5 1995 Sequence analysis of p53 cDNA revealed a homozygous double mutation at codon 249 (commonly mutated in aflatoxin-associated hepatocellular carcinoma) and codon 250. Aflatoxins 102-111 tumor protein p53 Homo sapiens 21-24 8033311-1 1994 Dietary aflatoxin and hepatitis B virus infection may play a role in generating the p53 tumor suppressor gene codon 249 hotspot mutation found in human hepatocellular carcinomas (HCCs) from Qidong (China) and southern Africa. Aflatoxins 8-17 tumor protein p53 Homo sapiens 84-87 8290606-6 1994 Mozambican-type of hepatocellular carcinomas are characterized by a high incidence of p53 mutations related to aflatoxins. Aflatoxins 111-121 tumor protein p53 Homo sapiens 86-89 8100480-1 1993 BACKGROUND: p53 gene mutations at codon 249 have been reported in hepatocellular carcinoma (HCC) from China and South Africa, a phenomenon shown to be closely associated with food contamination by aflatoxin. Aflatoxins 197-206 tumor protein p53 Homo sapiens 12-15 8307460-1 1994 p53 mutations are a common genetic finding in hepatocellular carcinoma from areas of high aflatoxin exposure. Aflatoxins 90-99 tumor protein p53 Homo sapiens 0-3 8307460-6 1994 This study shows that p53 mutations are a rare event in hepatocarcinogenesis in Great Britain, an area of low aflatoxin exposure, and supports the concept of geographical variations in the cause and pathogenesis of hepatocellular carcinoma. Aflatoxins 110-119 tumor protein p53 Homo sapiens 22-25 8790556-5 1994 Aflatoxins have been shown to induce specific mutations of the p53 tumour suppressor gene thus providing a clue to how an environmental factor may contribute to tumour development at the molecular level. Aflatoxins 0-10 tumor protein p53 Homo sapiens 63-66 8238731-1 1993 In areas of the world where hepatitis B and aflatoxin ingestion are common, alterations of the p53 tumor suppressor gene have frequently been reported in hepatocellular carcinoma (HCC). Aflatoxins 44-53 tumor protein p53 Homo sapiens 95-98 7583984-5 1993 In addition, the tumor suppressor gene p53 is frequently mutated in aflatoxin-induced hepatoma. Aflatoxins 68-77 tumor protein p53 Homo sapiens 39-42 8390289-1 1993 In hepatocellular carcinoma, mutation within the p53 gene occurs mainly at codon 249 and its frequency has been associated with exposure to aflatoxin. Aflatoxins 140-149 tumor protein p53 Homo sapiens 49-52 8390289-2 1993 As Senegal is a country where liver cancer incidence is one of the highest in the world and where people are highly exposed to aflatoxin, we screened 15 liver cancer samples from this country for mutation at codon 249 of the p53 gene. Aflatoxins 127-136 tumor protein p53 Homo sapiens 225-228 8093978-2 1993 Recently, there have been reports that p53 mutations are found to occur at high frequency (50%) in aflatoxin-related human primary hepatocellular carcinomas (HCC) (Hsu et al., 1991 Nature, vol 350, p. 427; Bressac et al., 1991 Nature, vol 350, p. 429). Aflatoxins 99-108 tumor protein p53 Homo sapiens 39-42 8393124-6 1993 These results suggest a role for other environmental factors, such as aflatoxin, in the etiology of p53 mutation in hepatocellular carcinoma in Oriental patients. Aflatoxins 70-79 tumor protein p53 Homo sapiens 100-103 1330867-6 1992 Our results showed that p53-positive hepatocellular carcinoma is a rare finding in patients exposed to a low dietary aflatoxin intake and that p53 mutation seems to occur at a late stage of the tumoral process and could contribute to an aggressive tumoral phenotype. Aflatoxins 117-126 tumor protein p53 Homo sapiens 24-27 1332921-7 1992 They support the suggestion of a possible link between dietary exposure to aflatoxin and selective G to T mutations at codon 249 of the p53 gene. Aflatoxins 75-84 tumor protein p53 Homo sapiens 136-139 1279184-0 1992 Mutations of p53 gene in hepatocellular carcinoma: roles of hepatitis B virus and aflatoxin contamination in the diet. Aflatoxins 82-91 tumor protein p53 Homo sapiens 13-16 1279184-2 1992 These reports suggested an association of p53 mutations with high levels of aflatoxin in the diet. Aflatoxins 76-85 tumor protein p53 Homo sapiens 42-45 1279184-5 1992 PURPOSE: The purpose of this study was to evaluate the relationship of p53 gene mutation to high or low levels of aflatoxin in the diet and to HBV infection. Aflatoxins 114-123 tumor protein p53 Homo sapiens 71-74 1279184-11 1992 CONCLUSION: Mutations of the tumor suppressor gene p53 in hepatocellular carcinomas are not limited to patients from geographic regions where the ingestion of aflatoxin is high. Aflatoxins 159-168 tumor protein p53 Homo sapiens 51-54 1394191-11 1992 The finding of transition mutations exclusively at GG sites may be of predictive value in attempts to link dietary aflatoxin exposure to cancers associated with specific mutations in the c-ras oncogene and the p53 tumor suppressor gene. Aflatoxins 115-124 tumor protein p53 Homo sapiens 210-213 1310637-7 1992 The occurrence of mutation in codon 249 of the p53 gene in selective samples of human hepatocellular cancers may indicate involvement of environmental carcinogens other than aflatoxin B1 or that hepatitis B virus-related hepatitis is a prerequisite for aflatoxin B1 induction of G to T transversion in codon 249. Aflatoxins 174-183 tumor protein p53 Homo sapiens 47-50 1347900-0 1992 p53 codon 249ser mutations in hepatocellular carcinoma patients with low aflatoxin exposure. Aflatoxins 73-82 tumor protein p53 Homo sapiens 0-3 1332185-3 1992 Recent reports of a guanine to thymine mutation of the third base of codon 249 of the tumour suppressor gene, p53, in 50% of patients with hepatocellular carcinoma in regions of high aflatoxin exposure, and mutagenic experiments showing that aflatoxin B1 binds particularly to guanine residues in G-C-rich domains and that codon 249 is a preferred target have suggested a mechanism whereby aflatoxin might induce malignant transformation. Aflatoxins 183-192 tumor protein p53 Homo sapiens 110-113 1332185-3 1992 Recent reports of a guanine to thymine mutation of the third base of codon 249 of the tumour suppressor gene, p53, in 50% of patients with hepatocellular carcinoma in regions of high aflatoxin exposure, and mutagenic experiments showing that aflatoxin B1 binds particularly to guanine residues in G-C-rich domains and that codon 249 is a preferred target have suggested a mechanism whereby aflatoxin might induce malignant transformation. Aflatoxins 242-251 tumor protein p53 Homo sapiens 110-113 1682737-0 1991 p53 mutation in hepatocellular carcinoma after aflatoxin exposure. Aflatoxins 47-56 tumor protein p53 Homo sapiens 0-3 1682737-9 1991 A codon 249 mutation of the p53 gene identifies an endemic form of HCC strongly associated with dietary aflatoxin intake. Aflatoxins 104-113 tumor protein p53 Homo sapiens 28-31