Imatinib Mesylate

MCL1 apoptosis regulator, BCL2 family member ; Homo sapiens







22 Article(s)
Download
PMID
Title
Pub. Year
#Total Relationships
1 33587348 LncRNA highly upregulated in liver cancer regulates imatinib resistance in chronic myeloid leukemia via the miR-150-5p/MCL1 axis. 2021 Apr 1 3
2 34564697 Combination of tyrosine kinase inhibitors and the MCL1 inhibitor S63845 exerts synergistic antitumorigenic effects on CML cells. 2021 Sep 25 1
3 32999756 Expression differences of miR-142-5p between treatment-naïve chronic myeloid leukemia patients responding and non-responding to imatinib therapy suggest a link to oncogenic ABL2, SRI, cKIT and MCL1 signaling pathways critical for development of therapy resistance. 2020 1
4 30866043 Neferine in the Lotus Plumule Potentiates the Antitumor Effect of Imatinib in Primary Chronic Myeloid Leukemia Cells In Vitro. 2019 Apr 1
5 31349760 The NEDD8-activating enzyme inhibitor MLN4924 induces DNA damage in Ph+ leukemia and sensitizes for ABL kinase inhibitors. 2019 Sep 1
6 30205168 Hydroxycoumarin OT-55 kills CML cells alone or in synergy with imatinib or Synribo: Involvement of ER stress and DAMP release. 2018 Dec 1 1
7 28319085 Synergistic drug combinations for cancer identified in a CRISPR screen for pairwise genetic interactions. 2017 May 1
8 26473951 Knockout Serum Replacement Promotes Cell Survival by Preventing BIM from Inducing Mitochondrial Cytochrome C Release. 2015 1
9 24088895 Activin A induction of erythroid differentiation sensitizes K562 chronic myeloid leukemia cells to a subtoxic concentration of imatinib. 2014 Jan 1 1
10 24947165 Anti-apoptotic effects of osteopontin through the up-regulation of Mcl-1 in gastrointestinal stromal tumors. 2014 Jun 20 2
11 23613979 Aclacinomycin A sensitizes K562 chronic myeloid leukemia cells to imatinib through p38MAPK-mediated erythroid differentiation. 2013 1
12 22033489 Activation of apoptosis signaling eliminates CD34+ progenitor cells in blast crisis CML independent of response to tyrosine kinase inhibitors. 2012 Apr 1
13 21195056 Bortezomib and sphingosine kinase inhibitor interact synergistically to induces apoptosis in BCR/ABl+ cells sensitive and resistant to STI571 through down-regulation Mcl-1. 2011 Feb 4 1
14 21220745 c-Abl regulates Mcl-1 gene expression in chronic lymphocytic leukemia cells. 2011 Feb 24 1
15 20153728 Spred2 is involved in imatinib-induced cytotoxicity in chronic myeloid leukemia cells. 2010 Mar 19 1
16 17110460 Identification of MCL1 as a novel target in neoplastic mast cells in systemic mastocytosis: inhibition of mast cell survival by MCL1 antisense oligonucleotides and synergism with PKC412. 2007 Apr 1 1
17 17595328 The multikinase inhibitor sorafenib induces apoptosis in highly imatinib mesylate-resistant bcr/abl+ human leukemia cells in association with signal transducer and activator of transcription 5 inhibition and myeloid cell leukemia-1 down-regulation. 2007 Sep 1
18 17926190 (-)Gossypol and its combination with imatinib induce apoptosis in human chronic myeloid leukemic cells. 2007 Nov 1
19 18088462 [STI571 induces apoptosis of K562 cells through down-regulation of anti-apoptotic protein Mcl-1 and Bcl-xl expression]. 2007 Dec 3
20 15626746 Identification of mcl-1 as a BCR/ABL-dependent target in chronic myeloid leukemia (CML): evidence for cooperative antileukemic effects of imatinib and mcl-1 antisense oligonucleotides. 2005 Apr 15 4
21 11782377 Pharmacologic mitogen-activated protein/extracellular signal-regulated kinase kinase/mitogen-activated protein kinase inhibitors interact synergistically with STI571 to induce apoptosis in Bcr/Abl-expressing human leukemia cells. 2002 Jan 1 1
22 12231544 Flavopiridol potentiates STI571-induced mitochondrial damage and apoptosis in BCR-ABL-positive human leukemia cells. 2002 Sep 1