Pub. Date : 2002 Jan 1
PMID : 11782377
1 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
1 | Synergistic potentiation of STI571-mediated lethality by PD184352 was associated with multiple perturbations in signaling and apoptotic regulatory pathways, including caspase-dependent down-regulation of Bcr-Abl and Bcl-2; caspase-independent down-regulation of Bcl-x(L) and Mcl-1; activation of JNK, p38 MAPK, and p34(cdc2); and diminished phosphorylation of Stat5 and CREB. | Imatinib Mesylate | MCL1 apoptosis regulator, BCL2 family member | Homo sapiens |