Title : Flavopiridol potentiates STI571-induced mitochondrial damage and apoptosis in BCR-ABL-positive human leukemia cells.

Pub. Date : 2002 Sep

PMID : 12231544






1 Functional Relationships(s)
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1 STI571/flavopiridol-mediated apoptosis was associated with the caspase-independent down-regulation of Bcl-x(L) and Mcl-1, activation of extracellular signal-regulated kinase and c-Jun NH(2)-terminal kinase, and the caspase-dependent release of Smac/DIABLO and loss of deltapsi(m). Imatinib Mesylate MCL1 apoptosis regulator, BCL2 family member Homo sapiens