Title : A Novel Combination Treatment with Honokiol and Rapamycin Effectively Restricts c-Met-Induced Growth of Renal Cancer Cells, and also Inhibits the Expression of Tumor Cell PD-L1 Involved in Immune Escape.

Pub. Date : 2020 Jul 3

PMID : 32635337






2 Functional Relationships(s)
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1 However, prolonged Rapamycin treatment re-activates Akt and can promote cancer growth. Sirolimus thymoma viral proto-oncogene 1 Mus musculus
2 We observed that compared with Rapamycin alone, Rapamycin + Honokiol combination can effectively down-regulate c-Met-induced Akt phosphorylation in renal cancer cells; and it markedly inhibited Ras activation and cell proliferation and promoted G1 phase cell cycle arrest. Sirolimus thymoma viral proto-oncogene 1 Mus musculus