Pub. Date : 2017 Aug 16
PMID : 28814333
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Rapamycin Prevents cyclophosphamide-induced Over-activation of Primordial Follicle pool through PI3K/Akt/mTOR Signaling Pathway in vivo. | Sirolimus | thymoma viral proto-oncogene 1 | Mus musculus |
| 2 | Compared to p-Akt/Akt and p-mtor/mtor, p-rps6/rps6 was significantly decreased in rapamycin + cyclophosphamide group (P < 0.05), indicating that rapamycin attenuated the increased level of phosphorylation of rpS6 after cyclophosphamide treatment. | Sirolimus | thymoma viral proto-oncogene 1 | Mus musculus |
| 3 | CONCLUSIONS: Rapamycin can prevent the primordial follicle activation induced by cyclophosphamide through PI3K/Akt/mTOR signaling pathway and thus plays a role in preserving the follicle pool. | Sirolimus | thymoma viral proto-oncogene 1 | Mus musculus |