Title : mTORC1-independent TFEB activation via Akt inhibition promotes cellular clearance in neurodegenerative storage diseases.

Pub. Date : 2017 Feb 6

PMID : 28165011






1 Functional Relationships(s)
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1 We show that Akt phosphorylates TFEB at Ser467 and represses TFEB nuclear translocation independently of mechanistic target of rapamycin complex 1 (mTORC1), a known TFEB inhibitor. Sirolimus thymoma viral proto-oncogene 1 Mus musculus