| 1 |
35505960 | RAB18 is a key regulator of GalNAc-conjugated siRNA-induced silencing in Hep3B cells. | 2022 Jun 14 |
2 |
| 2 |
32936032 | Lectin recognition and hepatocyte endocytosis of GalNAc-decorated nanostructured lipid carriers. | 2021 Jan |
3 |
| 3 |
33691403 | Discovery of Bivalent GalNAc-Conjugated Betulin as a Potent ASGPR-Directed Agent against Hepatocellular Carcinoma. | 2021 Apr 21 |
1 |
| 4 |
33861634 | Impact of Serum Proteins on the Uptake and RNAi Activity of GalNAc-Conjugated siRNAs. | 2021 Aug |
5 |
| 5 |
34037271 | Clinical Study of Single-Stranded Oligonucleotide RO7062931 in Healthy Volunteers and Patients With Chronic Hepatitis B. | 2021 Oct |
2 |
| 6 |
34085768 | PK/PD modeling of FXI antisense oligonucleotides to bridge the dose-FXI activity relation from healthy volunteers to end-stage renal disease patients. | 2021 Aug |
2 |
| 7 |
34154993 | The Nonclinical Disposition and PK/PD Properties of GalNAc-conjugated siRNA Are Highly Predictable and Build Confidence in Translation to Man. | 2021 Jun 21 |
1 |
| 8 |
34413198 | Minimal Physiologically Based Pharmacokinetic-Pharmacodynamic (mPBPK-PD) Model of N-Acetylgalactosamine-Conjugated Small Interfering RNA Disposition and Gene Silencing in Preclinical Species and Humans. | 2021 Nov |
1 |
| 9 |
34468210 | Programmed Instability of Ligand Conjugation Manifold for Efficient Hepatocyte Delivery of Therapeutic Oligonucleotides. | 2021 Dec |
1 |
| 10 |
32145269 | Different kinetics for the hepatic uptake of lipid nanoparticles between the apolipoprotein E/low density lipoprotein receptor and the N-acetyl-d-galactosamine/asialoglycoprotein receptor pathway. | 2020 Jun 10 |
3 |
| 11 |
32529829 | Receptor-Specific Delivery of Peptide Nucleic Acids Conjugated to Three Sequentially Linked N-Acetyl Galactosamine Moieties into Hepatocytes. | 2020 Jul 17 |
3 |
| 12 |
32650396 | ASGR1 and Its Enigmatic Relative, CLEC10A. | 2020 Jul 8 |
2 |
| 13 |
33424274 | Developed simvastatin chitosan nanoparticles co-crosslinked with tripolyphosphate and chondroitin sulfate for ASGPR-mediated targeted HCC delivery with enhanced oral bioavailability. | 2020 Dec |
1 |
| 14 |
31141333 | Triplex Hybridization of siRNA with Bifacial Glycopolymer Nucleic Acid Enables Hepatocyte-Targeted Silencing. | 2019 Jun 21 |
2 |
| 15 |
31529782 | Synthesis of Monovalent N-Acetylgalactosamine Phosphoramidite for Liver-Targeting Oligonucleotides. | 2019 Sep |
2 |
| 16 |
31726778 | Quantification of Surface GalNAc Ligands Decorating Nanostructured Lipid Carriers by UPLC-ELSD. | 2019 Nov 12 |
3 |
| 17 |
28988716 | Evaluation of GalNAc-siRNA Conjugate Activity in Pre-clinical Animal Models with Reduced Asialoglycoprotein Receptor Expression. | 2018 Jan 3 |
1 |
| 18 |
28325278 | Preclinical and Clinical Advances of GalNAc-Decorated Nucleic Acid Therapeutics. | 2017 Mar 17 |
2 |
| 19 |
28981809 | Impact of enhanced metabolic stability on pharmacokinetics and pharmacodynamics of GalNAc-siRNA conjugates. | 2017 Nov 2 |
1 |
| 20 |
28987883 | GalNAc bio-functionalization of nanoparticles assembled by electrostatic interactions improves siRNA targeting to the liver. | 2017 Nov 28 |
2 |
| 21 |
26678173 | Serial incorporation of a monovalent GalNAc phosphoramidite unit into hepatocyte-targeting antisense oligonucleotides. | 2016 Jan 1 |
1 |
| 22 |
26781030 | ASGPR-Mediated Uptake of Multivalent Glycoconjugates for Drug Delivery in Hepatocytes. | 2016 Apr 1 |
2 |
| 23 |
26854615 | N-Acetylgalactosamine Block-co-Polycations Form Stable Polyplexes with Plasmids and Promote Liver-Targeted Delivery. | 2016 Mar 14 |
2 |
| 24 |
25730476 | siRNA conjugates carrying sequentially assembled trivalent N-acetylgalactosamine linked through nucleosides elicit robust gene silencing in vivo in hepatocytes. | 2015 May 15 |
2 |
| 25 |
25786782 | Hepatocyte-specific delivery of siRNAs conjugated to novel non-nucleosidic trivalent N-acetylgalactosamine elicits robust gene silencing in vivo. | 2015 Apr 13 |
3 |
| 26 |
24975671 | Physiological roles of asialoglycoprotein receptors (ASGPRs) variants and recent advances in hepatic-targeted delivery of therapeutic molecules via ASGPRs. | 2014 |
1 |
| 27 |
20820666 | Design, synthesis and biological evaluation of carbohydrate-functionalized cyclodextrins and liposomes for hepatocyte-specific targeting. | 2010 Nov 7 |
1 |
| 28 |
18358727 | Trivalent, Gal/GalNAc-containing ligands designed for the asialoglycoprotein receptor. | 2008 May 1 |
2 |