Pub. Date : 2016 Mar 14
PMID : 26854615
2 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | The GalNAc-derived homopolymer effectively inhibited the uptake of Cy5-labeled asialofetuin (a natural ligand of ASGPRs) by cultured hepatocyte (HepG2) cells at lower concentrations (IC50 = 20 nM) than monomeric GalNAc (IC50 = 1 mM) and asialofetuin (IC50 = 1 muM), suggesting highly enhanced ASGPR binding due to multivalency. | N-acetylgalactosaminuronic acid | asialoglycoprotein receptor 1 | Homo sapiens |
| 2 | The GalNAc-derived homopolymer effectively inhibited the uptake of Cy5-labeled asialofetuin (a natural ligand of ASGPRs) by cultured hepatocyte (HepG2) cells at lower concentrations (IC50 = 20 nM) than monomeric GalNAc (IC50 = 1 mM) and asialofetuin (IC50 = 1 muM), suggesting highly enhanced ASGPR binding due to multivalency. | N-acetylgalactosaminuronic acid | asialoglycoprotein receptor 1 | Homo sapiens |