Title : Serial incorporation of a monovalent GalNAc phosphoramidite unit into hepatocyte-targeting antisense oligonucleotides.

Pub. Date : 2016 Jan 1

PMID : 26678173






1 Functional Relationships(s)
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1 The targeting of abundant hepatic asialoglycoprotein receptors (ASGPR) with trivalent N-acetylgalactosamine (GalNAc) is a reliable strategy for efficiently delivering antisense oligonucleotides (ASOs) to the liver. N-acetylgalactosaminuronic acid asialoglycoprotein receptor 1 Homo sapiens