Title : Receptor-Specific Delivery of Peptide Nucleic Acids Conjugated to Three Sequentially Linked N-Acetyl Galactosamine Moieties into Hepatocytes.

Pub. Date : 2020 Jul 17

PMID : 32529829






3 Functional Relationships(s)
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1 The work described here is motivated by recent reports of efficient gene silencing specifically in hepatocytes by small interfering RNAs (siRNAs) conjugated to triantennary N-acetylgalactosamine (GalNAc), the ligand recognized by the asialoglycoprotein receptor (ASGPR). N-acetylgalactosaminuronic acid asialoglycoprotein receptor 1 Homo sapiens
2 The work described here is motivated by recent reports of efficient gene silencing specifically in hepatocytes by small interfering RNAs (siRNAs) conjugated to triantennary N-acetylgalactosamine (GalNAc), the ligand recognized by the asialoglycoprotein receptor (ASGPR). N-acetylgalactosaminuronic acid asialoglycoprotein receptor 1 Homo sapiens
3 The fluorescently labeled analogs of GalNAc-conjugated PNAs were internalized by HepG2 cells that express the ASGPR but were not taken up by HEK293 cells that lack this receptor. N-acetylgalactosaminuronic acid asialoglycoprotein receptor 1 Homo sapiens