Title : Different kinetics for the hepatic uptake of lipid nanoparticles between the apolipoprotein E/low density lipoprotein receptor and the N-acetyl-d-galactosamine/asialoglycoprotein receptor pathway.

Pub. Date : 2020 Jun 10

PMID : 32145269






3 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 Trivalent N-acetyl-D-galactosamine (GalNAc) is known to be a high-affinity exogenous ligand against the asialoglycoprotein receptor (ASGPR), which is highly expressed on hepatocytes. N-acetylgalactosaminuronic acid asialoglycoprotein receptor 1 Homo sapiens
2 Trivalent N-acetyl-D-galactosamine (GalNAc) is known to be a high-affinity exogenous ligand against the asialoglycoprotein receptor (ASGPR), which is highly expressed on hepatocytes. N-acetylgalactosaminuronic acid asialoglycoprotein receptor 1 Homo sapiens
3 On the other hand, both blood clearance and cellular uptake were more gradual in the case of the exogenous GalNAc-ASGPR pathway. N-acetylgalactosaminuronic acid asialoglycoprotein receptor 1 Homo sapiens