Title : Hepatocyte-specific delivery of siRNAs conjugated to novel non-nucleosidic trivalent N-acetylgalactosamine elicits robust gene silencing in vivo.

Pub. Date : 2015 Apr 13

PMID : 25786782






3 Functional Relationships(s)
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1 We recently demonstrated that siRNAs conjugated to triantennary N-acetylgalactosamine (GalNAc) induce robust RNAi-mediated gene silencing in the liver, owing to uptake mediated by the asialoglycoprotein receptor (ASGPR). N-acetylgalactosaminuronic acid asialoglycoprotein receptor 1 Homo sapiens
2 We recently demonstrated that siRNAs conjugated to triantennary N-acetylgalactosamine (GalNAc) induce robust RNAi-mediated gene silencing in the liver, owing to uptake mediated by the asialoglycoprotein receptor (ASGPR). N-acetylgalactosaminuronic acid asialoglycoprotein receptor 1 Homo sapiens
3 The redesigned trivalent GalNAc ligand maintained optimal valency, spatial orientation, and distance between the sugar moieties for proper recognition by ASGPR. N-acetylgalactosaminuronic acid asialoglycoprotein receptor 1 Homo sapiens