Tyrosine

phospholipase C gamma 1 ; Homo sapiens







200 Article(s)
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1 35124007 In vitro reconstitution reveals cooperative mechanisms of adapter protein-mediated activation of phospholipase C-γ1 in T cells. 2022 Mar 2
2 32304729 Metabotropic signaling cascade involved in α4β2 nicotinic acetylcholine receptor-mediated PKCβII activation. 2020 Aug 1
3 31889510 Structural basis for the activation of PLC-γ isozymes by phosphorylation and cancer-associated mutations. 2019 Dec 31 1
4 29524543 A phosphoglycolate phosphatase/AUM-dependent link between triacylglycerol turnover and epidermal growth factor signaling. 2018 Jun 1
5 30165102 β-Heregulin impairs EGF induced PLC-γ1 signalling in human breast cancer cells. 2018 Dec 1
6 28644030 A PLC-γ1 Feedback Pathway Regulates Lck Substrate Phosphorylation at the T-Cell Receptor and SLP-76 Complex. 2017 Aug 4 1
7 25316710 SRC homology 2 domain-containing leukocyte phosphoprotein of 76 kDa (SLP-76) N-terminal tyrosine residues regulate a dynamic signaling equilibrium involving feedback of proximal T-cell receptor (TCR) signaling. 2015 Jan 3
8 25734483 CD47 agonist peptides induce programmed cell death in refractory chronic lymphocytic leukemia B cells via PLCγ1 activation: evidence from mice and humans. 2015 Mar 1
9 25916191 Scaffold Protein SLP-76 Primes PLCγ1 for Activation by ITK-Mediated Phosphorylation. 2015 Aug 28 2
10 24412752 Activated PLC-γ1 is catalytically induced at LAT but activated PLC-γ1 is localized at both LAT- and TCR-containing complexes. 2014 Apr 2
11 23219468 Substrate recognition of PLCγ1 via a specific docking surface on Itk. 2013 Feb 22 1
12 23613900 PKG II inhibits EGF/EGFR-induced migration of gastric cancer cells. 2013 2
13 23880762 Mitochondria-derived hydrogen peroxide selectively enhances T cell receptor-initiated signal transduction. 2013 Sep 6 1
14 22454520 A novel regulatory mechanism links PLCγ1 to PDK1. 2012 Jul 1 2
15 21123182 Identification of new substrates of the protein-tyrosine phosphatase PTP1B by Bayesian integration of proteome evidence. 2011 Feb 11 1
16 21463338 Ethanol inhibits lipid raft-mediated TCR signaling and IL-2 expression: potential mechanism of alcohol-induced immune suppression. 2011 Aug 1
17 21471003 Tyrosine phosphorylation-dependent activation of TRPC6 regulated by PLC-γ1 and nephrin: effect of mutations associated with focal segmental glomerulosclerosis. 2011 Jun 1 2
18 21760611 The death receptor CD95 activates the cofilin pathway to stimulate tumour cell invasion. 2011 Sep 1 1
19 19166869 EGF-receptor phosphorylation and downstream signaling are activated by benzo[a]pyrene 3,6-quinone and benzo[a]pyrene 1,6-quinone in human mammary epithelial cells. 2009 Mar 15 3
20 19179337 Phosphorylation of Nephrin Triggers Ca2+ Signaling by Recruitment and Activation of Phospholipase C-{gamma}1. 2009 Mar 27 6
21 19427038 PI3 kinase function is vital for the function but not formation of LAT-mediated signaling complexes. 2009 Jul 1
22 19716804 Erkitinib, a novel EGFR tyrosine kinase inhibitor screened using a ProteoChip system from a phytochemical library. 2009 Nov 20 1
23 18004076 Activation of phospholipase C gamma 1 protects renal arteriolar VSMCs from H2O2-induced cell death. 2008 2
24 17116690 Intramolecular regulation of phospholipase C-gamma1 by its C-terminal Src homology 2 domain. 2007 Feb 3
25 17220479 CD2 and TCR synergize for the activation of phospholipase Cgamma1/calcium pathway at the immunological synapse. 2007 Mar 1
26 17372230 A critical role for the E3-ligase activity of c-Cbl in VEGFR-2-mediated PLCgamma1 activation and angiogenesis. 2007 Mar 27 2
27 17439160 A remote substrate docking mechanism for the tec family tyrosine kinases. 2007 May 8 1
28 17494698 EphA4 signaling regulates phospholipase Cgamma1 activation, cofilin membrane association, and dendritic spine morphology. 2007 May 9 1
29 17561374 Protein kinase Cepsilon may act as EGF-inducible scaffold protein for phospholipase Cgamma1. 2007 Sep 8
30 17652306 Keeping the (kinase) party going: SLP-76 and ITK dance to the beat. 2007 Jul 24 1
31 15936927 Peptide growth factors signal differentially through protein kinase C to extracellular signal-regulated kinases in neonatal cardiomyocytes. 2006 Feb 1
32 16467851 Recruitment and activation of PLCgamma1 in T cells: a new insight into old domains. 2006 Feb 22 3
33 16636972 Effects of resveratrol on mast cell degranulation and tyrosine phosphorylation of the signaling components of the IgE receptor. 2006 Jun 2
34 17050525 Vav1 acidic region tyrosine 174 is required for the formation of T cell receptor-induced microclusters and is essential in T cell development and activation. 2006 Dec 15 3
35 15623534 T cell receptor-induced activation of phospholipase C-gamma1 depends on a sequence-independent function of the P-I region of SLP-76. 2005 Mar 4 2
36 15641795 NMR dynamics-derived insights into the binding properties of a peptide interacting with an SH2 domain. 2005 Jan 18 1
37 15657076 Integrin-dependent PLC-gamma1 phosphorylation mediates fibronectin-dependent adhesion. 2005 Feb 1 2
38 15673613 The carboxyl terminus of VEGFR-2 is required for PKC-mediated down-regulation. 2005 Apr 1
39 15764700 Intramolecular interaction between phosphorylated tyrosine-783 and the C-terminal Src homology 2 domain activates phospholipase C-gamma1. 2005 Mar 22 1
40 16038803 Grb2 negatively regulates epidermal growth factor-induced phospholipase C-gamma1 activity through the direct interaction with tyrosine-phosphorylated phospholipase C-gamma1. 2005 Oct 5
41 16081816 Early phosphorylation kinetics of proteins involved in proximal TCR-mediated signaling pathways. 2005 Aug 15 1
42 16291968 A cyclic adenosine 3',5'-monophosphate stimulates phospholipase Cgamma1-calcium signaling via the activation of tyrosine kinase in boar spermatozoa. 2005 Nov-Dec 1
43 16706231 [EGF-dependent signaling pathways are activated under heat stress in A431 carcinoma cells]. 2005 1
44 14710234 Antitumour effects of PLC-gamma1-(SH2)2-TAT fusion proteins on EGFR/c-erbB-2-positive breast cancer cells. 2004 Jan 12 1
45 15214048 Positive feedback regulation of PLCgamma1/Ca(2+) signaling by PKCtheta in restimulated T cells via a Tec kinase-dependent pathway. 2004 Jul 1
46 12496416 Minimal requirement of tyrosine residues of linker for activation of T cells in TCR signaling and thymocyte development. 2003 Jan 1 1
47 12598525 Recruitment and activation of phospholipase Cgamma1 by vascular endothelial growth factor receptor-2 are required for tubulogenesis and differentiation of endothelial cells. 2003 May 2 4
48 12717426 70Z/3 Cbl induces PLC gamma 1 activation in T lymphocytes via an alternate Lat- and Slp-76-independent signaling mechanism. 2003 Apr 24 1
49 12771140 Src kinase mediates the regulation of phospholipase C-gamma activity by glycosphingolipids. 2003 Aug 15 6
50 12866655 Retinoic acid maintains differentiated cell morphology and functions in long-term cultured porcine hepatocytes: obtaining functional cells for prolonged treatments with bioartificial liver. 2003 Jun 1