Title : EGF-receptor phosphorylation and downstream signaling are activated by benzo[a]pyrene 3,6-quinone and benzo[a]pyrene 1,6-quinone in human mammary epithelial cells.

Pub. Date : 2009 Mar 15

PMID : 19166869






3 Functional Relationships(s)
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1 In the present study we demonstrated that BPQs not only induced EGFR tyrosine autophosphorylation, but also induced EGFR-dependent tyrosine phosphorylation of phospholipase C-gamma1 and several signal transducers and activators of transcription (STATs). Tyrosine phospholipase C gamma 1 Homo sapiens
2 PLC-gamma1 phosphorylation correlated with the phosphorylation of tyrosine-Y992, a proposed docking site for PLC-gamma1 on the EGFR. Tyrosine phospholipase C gamma 1 Homo sapiens
3 PLC-gamma1 phosphorylation correlated with the phosphorylation of tyrosine-Y992, a proposed docking site for PLC-gamma1 on the EGFR. Tyrosine phospholipase C gamma 1 Homo sapiens