Pub. Date : 2005 Oct
PMID : 16038803
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Grb2 negatively regulates epidermal growth factor-induced phospholipase C-gamma1 activity through the direct interaction with tyrosine-phosphorylated phospholipase C-gamma1. | Tyrosine | phospholipase C gamma 1 | Homo sapiens |
| 2 | Grb2 negatively regulates epidermal growth factor-induced phospholipase C-gamma1 activity through the direct interaction with tyrosine-phosphorylated phospholipase C-gamma1. | Tyrosine | phospholipase C gamma 1 | Homo sapiens |
| 3 | In this study, we demonstrate for the first time that Grb2, an adaptor protein, specifically interacts with tyrosine-phosphorylated PLC-gamma1 at Tyr783. | Tyrosine | phospholipase C gamma 1 | Homo sapiens |
| 4 | Replacement of Tyr783 with Phe completely blocked EGF-induced interaction of PLC-gamma1 with Grb2, indicating that tyrosine phosphorylation of PLC-gamma1 at Tyr783 is essential for the interaction with Grb2. | Tyrosine | phospholipase C gamma 1 | Homo sapiens |
| 5 | Replacement of Tyr783 with Phe completely blocked EGF-induced interaction of PLC-gamma1 with Grb2, indicating that tyrosine phosphorylation of PLC-gamma1 at Tyr783 is essential for the interaction with Grb2. | Tyrosine | phospholipase C gamma 1 | Homo sapiens |