2-Aminopurine

⇄

eukaryotic translation initiation factor 2 alpha kinase 2 ; Homo sapiens







39 Article(s)
Download
PMID
Title
Pub. Year
#Total Relationships
1 31762232 [Molecular Mechanisms of Apoptosis of Leukemia Cell Induced by Reovirus]. 2019 Sep 1
2 29906232 Novel role of PKR in palmitate-induced Sirt1 inactivation and endothelial cell senescence. 2018 Sep 1 1
3 27929137 Inhibition of PKR protects against H2O2-induced injury on neonatal cardiac myocytes by attenuating apoptosis and inflammation. 2016 Dec 8 2
4 22268531 The non-steroidal anti-inflammatory drug indomethacin activates the eIF2α kinase PKR, causing a translational block in human colorectal cancer cells. 2012 Apr 15 2
5 22750230 Mechanism of inhibition of lipopolysaccharide-induced interferon-β production by 2-aminopurine. 2012 Oct 2
6 21051868 Induction of B cell-activating factor by viral infection is a general phenomenon, but the types of viruses and mechanisms depend on cell type. 2011 1
7 21377708 Activation of protein kinase R is required for induction of stress granules by respiratory syncytial virus but dispensable for viral replication. 2011 Apr 25 4
8 21468538 Selective leukemia cell death by activation of the double-stranded RNA-dependent protein kinase PKR. 2011 Aug 2
9 21861882 Differential toll-like receptor 3 (TLR3) expression and apoptotic response to TLR3 agonist in human neuroblastoma cells. 2011 Aug 23 1
10 21901118 Aquatic birnavirus-induced ER stress-mediated death signaling contribute to downregulation of Bcl-2 family proteins in salmon embryo cells. 2011 4
11 20171114 A role for protein kinase PKR in the mediation of Epstein-Barr virus latent membrane protein-1-induced IL-6 and IL-10 expression. 2010 May 5
12 19201880 IL-10-dependent S100A8 gene induction in monocytes/macrophages by double-stranded RNA. 2009 Feb 15 2
13 19349624 Activation of host antiviral RNA-sensing factors necessary for herpes simplex virus type 1-activated transcription of host cell fucosyltransferase genes FUT3, FUT5, and FUT6 and subsequent expression of sLe(x) in virus-infected cells. 2009 Jul 4
14 19440231 Herpes simplex virus delivery to orthotopic rectal carcinoma results in an efficient and selective antitumor effect. 2009 Jul 1
15 19559408 TLR4-independent and PKR-dependent interleukin 1 receptor antagonist expression upon LPS stimulation. 2009 2
16 18599499 Double-stranded RNA-activated protein kinase mediates induction of interleukin-8 expression by deoxynivalenol, Shiga toxin 1, and ricin in monocytes. 2008 Oct 3
17 16516295 IFN-gamma-induced upregulation of Fcgamma-receptor-I during activation of monocytic cells requires the PKR and NFkappaB pathways. 2007 Jan 3
18 17014383 Double-stranded RNA-dependent protein kinase is involved in 2-methoxyestradiol-mediated cell death of osteosarcoma cells. 2007 Jan 2
19 17899538 Specific TLR ligands regulate APRIL secretion by dendritic cells in a PKR-dependent manner. 2007 Oct 3
20 16324719 Double-stranded RNA-dependent protein kinase (PKR) is a stress-responsive kinase that induces NFkappaB-mediated resistance against mercury cytotoxicity. 2006 Mar 13 2
21 16645989 "Endogenous adjuvant" activity of the RNA components of lupus autoantigens Sm/RNP and Ro 60. 2006 May 2
22 17070518 2-Aminopurine inhibits leptin receptor signal transduction. 2006 Dec 28 2
23 17142740 Innate cytokine responses in porcine macrophage populations: evidence for differential recognition of double-stranded RNA. 2006 Dec 15 2
24 15515120 Double-stranded secondary structures on mRNA induce type I interferon (IFN alpha/beta) production and maturation of mRNA-transfected monocyte-derived dendritic cells. 2005 Apr 2
25 16291516 Double-stranded RNA induces the synthesis of retinoic acid-inducible gene-I in vascular endothelial cells. 2005 May-Jun 1
26 16301626 A role for double-stranded RNA-activated protein kinase PKR in Mycobacterium-induced cytokine expression. 2005 Dec 1 1
27 16502342 Polyinosinic-polycytidylic acid induces the expression of GRO-alpha in BEAS-2B cells. 2005 Feb 1
28 15229216 Protein kinase R (PKR) interacts with and activates mitogen-activated protein kinase kinase 6 (MKK6) in response to double-stranded RNA stimulation. 2004 Sep 3 2
29 15299030 The Fanconi anemia proteins functionally interact with the protein kinase regulated by RNA (PKR). 2004 Oct 15 2
30 12600836 Double-stranded RNA induces the synthesis of specific chemokines by bronchial epithelial cells. 2003 Jun 1
31 11832212 Human interferon-gamma mRNA autoregulates its translation through a pseudoknot that activates the interferon-inducible protein kinase PKR. 2002 Jan 25 2
32 11956076 Adenoviral transfer of the melanoma differentiation-associated gene 7 (mda7) induces apoptosis of lung cancer cells via up-regulation of the double-stranded RNA-dependent protein kinase (PKR). 2002 Apr 15 2
33 11148216 Ceramide regulates protein synthesis by a novel mechanism involving the cellular PKR activator RAX. 2001 Apr 13 2
34 11338389 Inhibition of porcine reproductive and respiratory syndrome virus by interferon-gamma and recovery of virus replication with 2-aminopurine. 2001 3
35 9988719 Involvement of double-stranded RNA-activated protein kinase in the synergistic activation of nuclear factor-kappaB by tumor necrosis factor-alpha and gamma-interferon in preneuronal cells. 1999 Feb 19 2
36 9437407 Elevated apoptotic cell population in patients with chronic fatigue syndrome: the pivotal role of protein kinase RNA. 1997 Dec 2
37 7531699 Platelet-derived growth factor signal transduction through the interferon-inducible kinase PKR. Immediate early gene induction. 1995 Feb 17 3
38 7693978 Mechanism of interferon action: evidence for intermolecular autophosphorylation and autoactivation of the interferon-induced, RNA-dependent protein kinase PKR. 1993 Dec 4
39 7905506 2-Aminopurine inhibits the double-stranded RNA-dependent protein kinase both in vitro and in vivo. 1993 Oct 1