Title : Protein kinase R (PKR) interacts with and activates mitogen-activated protein kinase kinase 6 (MKK6) in response to double-stranded RNA stimulation.

Pub. Date : 2004 Sep 3

PMID : 15229216






2 Functional Relationships(s)
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Compound Name
Protein Name
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1 In cells pre-exposed to the PKR inhibitor 2-aminopurine or in PKR-null cells, the activation of p38 mitogen-activated protein kinase (MAPK) following dsRNA stimulation is attenuated. 2-Aminopurine eukaryotic translation initiation factor 2 alpha kinase 2 Homo sapiens
2 In vitro kinase assays revealed that MKK6 was efficiently phosphorylated by PKR, and this could be inhibited by 2-aminopurine. 2-Aminopurine eukaryotic translation initiation factor 2 alpha kinase 2 Homo sapiens