Title : Double-stranded RNA-activated protein kinase mediates induction of interleukin-8 expression by deoxynivalenol, Shiga toxin 1, and ricin in monocytes.

Pub. Date : 2008 Oct

PMID : 18599499






3 Functional Relationships(s)
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Protein Name
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1 Preincubation of human monocytic U937 cells with the PKR inhibitors C16 and 2-aminopurine (2-AP) blocked DON-induced expression of IL-8 protein and mRNA. 2-Aminopurine eukaryotic translation initiation factor 2 alpha kinase 2 Homo sapiens
2 Preincubation of human monocytic U937 cells with the PKR inhibitors C16 and 2-aminopurine (2-AP) blocked DON-induced expression of IL-8 protein and mRNA. 2-Aminopurine eukaryotic translation initiation factor 2 alpha kinase 2 Homo sapiens
3 As observed for DON, ricin-, and Stx1-induced IL-8 expression was suppressed by the PKR inhibitors C16 and 2-AP as well as impaired in UK9M cells. 2-Aminopurine eukaryotic translation initiation factor 2 alpha kinase 2 Homo sapiens