Title : Ceramide regulates protein synthesis by a novel mechanism involving the cellular PKR activator RAX.

Pub. Date : 2001 Apr 13

PMID : 11148216






2 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 Since 2-aminopurine, a serine/threonine kinase inhibitor that has previously been shown to inhibit PKR, blocks both the potentiation of ceramide killing by RAX and ceramide-induced inhibition of protein synthesis, ceramide appears to promote PKR activation, at least indirectly. 2-Aminopurine eukaryotic translation initiation factor 2 alpha kinase 2 Homo sapiens
2 Since 2-aminopurine, a serine/threonine kinase inhibitor that has previously been shown to inhibit PKR, blocks both the potentiation of ceramide killing by RAX and ceramide-induced inhibition of protein synthesis, ceramide appears to promote PKR activation, at least indirectly. 2-Aminopurine eukaryotic translation initiation factor 2 alpha kinase 2 Homo sapiens