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33535955 | MGMT Epigenetics: The Influence of Gene Body Methylation and Other Insights Derived from Integrated Methylomic, Transcriptomic, and Chromatin Analyses in Various Cancer Types. | 2021 |
4 |
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32109525 | Glycolytic inhibition by 3-bromopyruvate increases the cytotoxic effects of chloroethylnitrosoureas to human glioma cells and the DNA interstrand cross-links formation. | 2020 Apr 15 |
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| 3 |
30449727 | Ubiquitin-conjugating enzyme E2 B regulates the ubiquitination of O6-methylguanine-DNA methyltransferase and BCNU sensitivity in human nasopharyngeal carcinoma cells. | 2018 Dec |
5 |
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28484518 | Importance of biomarkers in glioblastomas patients receiving local BCNU wafer chemotherapy. | 2017 |
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| 5 |
28644958 | Translating cancer epigenomics into the clinic: focus on lung cancer. | 2017 Nov |
1 |
| 6 |
26865253 | Chemotherapy with BCNU in recurrent glioma: Analysis of clinical outcome and side effects in chemotherapy-naïve patients. | 2016 Feb 10 |
1 |
| 7 |
27845303 | New insights into estrogenic regulation of O6-methylguanine DNA-methyltransferase (MGMT) in human breast cancer cells: Co-degradation of ER-α and MGMT proteins by fulvestrant or O6-benzylguanine indicates fresh avenues for therapy. | 2016 Sep |
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26622581 | Leukemia cells are sensitized to temozolomide, carmustine and melphalan by the inhibition of O6-methylguanine-DNA methyltransferase. | 2015 Aug |
2 |
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23122841 | Loss of O⁶-methylguanine-DNA methyltransferase confers collateral sensitivity to carmustine in topoisomerase II-mediated doxorubicin resistant triple negative breast cancer cells. | 2013 Jan 15 |
2 |
| 10 |
23662801 | MGMT promoter methylation status and prognosis of patients with primary or recurrent glioblastoma treated with carmustine wafers. | 2013 Dec |
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23946891 | Expression of O6-Methylguanine-DNA Methyltransferase Examined by Alkyl-Transfer Assays, Methylation-Specific PCR and Western Blots in Tumors and Matched Normal Tissue. | 2013 Jun |
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| 12 |
22244911 | O(6)-methylguanine-DNA methyltransferase in glioma therapy: promise and problems. | 2012 Aug |
2 |
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22359215 | O(6) -methylguanine-DNA methyltransferase (MGMT) promoter methylation and low MGMT-encoded protein expression as prognostic markers in glioblastoma patients treated with biodegradable carmustine wafer implants after initial surgery followed by radiotherapy with concomitant and adjuvant temozolomide. | 2012 Sep 15 |
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| 14 |
22627392 | In vivo selection of autologous MGMT gene-modified cells following reduced-intensity conditioning with BCNU and temozolomide in the dog model. | 2012 Aug |
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| 15 |
22040411 | Silencing of MGMT with small interference RNA reversed resistance in human BCUN-resistant glioma cell lines. | 2011 Sep |
5 |
| 16 |
20043672 | Extended O6-methylguanine methyltransferase promoter hypermethylation following n-butylidenephthalide combined with 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU) on inhibition of human hepatocellular carcinoma cell growth. | 2010 Feb 10 |
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| 17 |
20167086 | Promoter methylation analysis of O6-methylguanine-DNA methyltransferase in glioblastoma: detection by locked nucleic acid based quantitative PCR using an imprinted gene (SNURF) as a reference. | 2010 Feb 18 |
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20556481 | Can high-dose fotemustine reverse MGMT resistance in glioblastoma multiforme? | 2010 Nov |
2 |
| 19 |
20706757 | First-line treatment of malignant glioma with carmustine implants followed by concomitant radiochemotherapy: a multicenter experience. | 2010 Oct |
1 |
| 20 |
20980775 | Influence of cell cycle checkpoints and p53 function on the toxicity of temozolomide in human pancreatic cancer cells. | 2010 |
2 |
| 21 |
18633619 | BCNU-sequestration by metallothioneins may contribute to resistance in a medulloblastoma cell line. | 2009 Mar |
2 |
| 22 |
19048410 | Suppression of HLA expression by lentivirus-mediated gene transfer of siRNA cassettes and in vivo chemoselection to enhance hematopoietic stem cell transplantation. | 2009 |
2 |
| 23 |
19637364 | Prognostic impact of O6-methylguanine-DNA methyltransferase silencing in patients with recurrent glioblastoma multiforme who undergo surgery and carmustine wafer implantation: a prospective patient cohort. | 2009 Oct 15 |
2 |
| 24 |
18192231 | Bone marrow-derived cells exhibiting lung epithelial cell characteristics are enriched in vivo using methylguanine DNA methyltransferase-mediated drug resistance. | 2008 Mar |
6 |
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18492797 | Transcriptional repression of O6-methylguanine DNA methyltransferase gene rendering cells hypersensitive to N,N'-bis(2-chloroethyl)-N-nitrosurea in camptothecin-resistant cells. | 2008 Aug |
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| 26 |
17354015 | O6-benzylguanine and BCNU in multiple myeloma: a phase II trial. | 2007 Aug |
5 |
| 27 |
17597106 | Tamoxifen accelerates proteasomal degradation of O6-methylguanine DNA methyltransferase in human cancer cells. | 2007 Nov 15 |
2 |
| 28 |
16432170 | Differential competitive resistance to methylating versus chloroethylating agents among five O6-alkylguanine DNA alkyltransferases in human hematopoietic cells. | 2006 Jan |
5 |
| 29 |
16520986 | A phase II trial of O6-benzylguanine and carmustine in patients with advanced soft tissue sarcoma. | 2006 Nov |
4 |
| 30 |
15735757 | Inactivated MGMT by O6-benzylguanine is associated with prolonged G2/M arrest in cancer cells treated with BCNU. | 2005 Mar 24 |
9 |
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15814657 | O6-methylguanine-DNA methyltransferase, O6-benzylguanine, and resistance to clinical alkylators in pediatric primary brain tumor cell lines. | 2005 Apr 1 |
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| 32 |
15833865 | Mitochondrial targeting of human O6-methylguanine DNA methyltransferase protects against cell killing by chemotherapeutic alkylating agents. | 2005 Apr 15 |
2 |
| 33 |
14712205 | Generating mutations but providing chemosensitivity: the role of O6-methylguanine DNA methyltransferase in human cancer. | 2004 Jan 8 |
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14742745 | Hammerhead ribozyme-mediated sensitization of human tumor cells after treatment with 1,3-bis(2-chloroethyl)-1-nitrosourea. | 2004 May |
6 |
| 35 |
15053863 | Cloning and expression of canine O6-methylguanine-DNA methyltransferase in target cells, using gammaretroviral and lentiviral vectors. | 2004 Apr |
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| 36 |
15194059 | Limited lentiviral transgene expression with increasing copy number in an MGMT selection model: lack of copy number selection by drug treatment. | 2004 Jun |
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15297393 | CpG island hypermethylation of the DNA repair enzyme methyltransferase predicts response to temozolomide in primary gliomas. | 2004 Aug 1 |
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| 38 |
12684420 | O6-methyl-guanine-DNA methyltransferase methylation in serum and tumor DNA predicts response to 1,3-bis(2-chloroethyl)-1-nitrosourea but not to temozolamide plus cisplatin in glioblastoma multiforme. | 2003 Apr |
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| 39 |
12850483 | SarCNU mediates selection of P140K methylguanine-DNA-methyltransferase transduced human CD34(+) cells in vitro. | 2003 Jul-Aug |
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| 40 |
14670122 | In vivo selection of human hematopoietic cells in a xenograft model using combined pharmacologic and genetic manipulations. | 2003 Dec 10 |
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14707273 | Hematopoietic expression of O(6)-methylguanine DNA methyltransferase-P140K allows intensive treatment of human glioma xenografts with combination O(6)-benzylguanine and 1,3-bis-(2-chloroethyl)-1-nitrosourea. | 2003 Dec |
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11945064 | Lentiviral transduction of P140K MGMT into human CD34(+) hematopoietic progenitors at low multiplicity of infection confers significant resistance to BG/BCNU and allows selection in vitro. | 2002 Apr |
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11238017 | Reduction of BCNU toxicity to lung cells by high-level expression of O(6)-methylguanine-DNA methyltransferase. | 2001 Apr |
5 |
| 44 |
11303039 | Comparison of single- versus double-bolus treatments of O(6)-benzylguanine for depletion of O(6)-methylguanine DNA methyltransferase (MGMT) activity in vivo: development of a novel fluorometric oligonucleotide assay for measurement of MGMT activity. | 2001 May |
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11350911 | Enforced expression of wild-type p53 curtails the transcription of the O(6)-methylguanine-DNA methyltransferase gene in human tumor cells and enhances their sensitivity to alkylating agents. | 2001 May |
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| 46 |
11351250 | Heterogeneous methylation of the O(6)-methylguanine-DNA methyltransferase promoter in immortalized IMR90 cell lines. | 2001 Jun |
6 |
| 47 |
11408535 | Modulation of 1,3-bis-(2-chloroethyl)-1-nitrosourea resistance in human tumor cells using hammerhead ribozymes designed to degrade O6-methylguanine DNA methyltransferase mRNA. | 2001 Jul |
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| 48 |
11672516 | G156A MGMT-transduced human mesenchymal stem cells can be selectively enriched by O6-benzylguanine and BCNU. | 2001 Oct |
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| 49 |
10933201 | Protection of hematopoietic cells against combined O6-benzylguanine and chloroethylnitrosourea treatment by mutant forms of O6-methylguanine DNA methyltransferase. | 2000 May |
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10942771 | Regulation of the human O(6)-methylguanine-DNA methyltransferase gene by transcriptional coactivators cAMP response element-binding protein-binding protein and p300. | 2000 Nov 3 |
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