Pub. Date : 2007 Aug
PMID : 17354015
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | PURPOSE: Carmustine (BCNU) is known to have modest activity in multiple myeloma; however, resistance to BCNU manifests by the activity of O6-methylguanine methyltransferase (MGMT). | Carmustine | O-6-methylguanine-DNA methyltransferase | Homo sapiens |
| 2 | PURPOSE: Carmustine (BCNU) is known to have modest activity in multiple myeloma; however, resistance to BCNU manifests by the activity of O6-methylguanine methyltransferase (MGMT). | Carmustine | O-6-methylguanine-DNA methyltransferase | Homo sapiens |
| 3 | PURPOSE: Carmustine (BCNU) is known to have modest activity in multiple myeloma; however, resistance to BCNU manifests by the activity of O6-methylguanine methyltransferase (MGMT). | Carmustine | O-6-methylguanine-DNA methyltransferase | Homo sapiens |
| 4 | The objective of this study was to determine the safety and efficacy of depletion of MGMT activity in plasma cells using O6-benzylguanine (O6-BG) with BCNU in patients with multiple myeloma. | Carmustine | O-6-methylguanine-DNA methyltransferase | Homo sapiens |
| 5 | CONCLUSIONS: Chemotherapy utilizing the MGMT inhibitor O6-benzylguanine and BCNU results in inhibition of MGMT activity in malignant plasma cells and produces meaningful responses in a modest proportion of patients with multiple myeloma. | Carmustine | O-6-methylguanine-DNA methyltransferase | Homo sapiens |