Pub. Date : 2003 Apr
PMID : 12684420
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | O6-methyl-guanine-DNA methyltransferase methylation in serum and tumor DNA predicts response to 1,3-bis(2-chloroethyl)-1-nitrosourea but not to temozolamide plus cisplatin in glioblastoma multiforme. | Carmustine | O-6-methylguanine-DNA methyltransferase | Homo sapiens |
| 2 | PURPOSE: In glioblastoma multiforme (GBM), the cytotoxic effect of 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU) and temozolamide is dependent on O(6) alkylation, which correlates inversely with expression of the DNA repair enzyme O(6)-methyl-guanine-DNA methyltransferase (MGMT). | Carmustine | O-6-methylguanine-DNA methyltransferase | Homo sapiens |
| 3 | EXPERIMENTAL DESIGN: Using MSP assay, we assessed the methylation of MGMT, p16, DAPK, and RASSF1A in tumor and serum DNA from 28 GBM patients treated with BCNU or with temozolamide plus cisplatin. | Carmustine | O-6-methylguanine-DNA methyltransferase | Homo sapiens |
| 4 | In the 16 patients treated with temozolamide plus cisplatin, no significant correlation between MGMT methylation status and response was observed, whereas in BCNU-treated patients, a significant difference was observed in favor of those with methylated MGMT. | Carmustine | O-6-methylguanine-DNA methyltransferase | Homo sapiens |
| 5 | Serum MGMT methylation predicted response and time to progression in BCNU-treated GBM patients. | Carmustine | O-6-methylguanine-DNA methyltransferase | Homo sapiens |