Title : Generating mutations but providing chemosensitivity: the role of O6-methylguanine DNA methyltransferase in human cancer.

Pub. Date : 2004 Jan 8

PMID : 14712205






1 Functional Relationships(s)
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Protein Name
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1 MGMT removes mutagenic and cytotoxic adducts from O(6)-guanine in DNA, the preferred point of attack of many carcinogens (i.e. methylnitrosourea) and alkylating chemotherapeutic agents (i.e. BCNU, temozolamide, etc.). Carmustine O-6-methylguanine-DNA methyltransferase Homo sapiens