Title : Differences in cytochrome P450 forms involved in the metabolism of N,N-dipropyl-2-[4-methoxy-3-(2-phenylethoxy)phenyl]ethylamine monohydrochloride (NE-100), a novel sigma ligand, in human liver and intestine.

Pub. Date : 2003 Jan

PMID : 12485954






1 Functional Relationships(s)
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1 A significant correlation was observed between activities of NE-100 metabolism and dextromethorphan O-demethylation (a specific activity for CYP2D6) or testosterone 6beta-hydroxylation (a specific activity for CYP3A4) in HLM. Dextromethorphan cytochrome P450 family 2 subfamily D member 6 Homo sapiens