Caffeine

cytochrome P450, family 1, subfamily a, polypeptide 2 ; Rattus norvegicus







32 Article(s)
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1 32047430 Regulation of X-Ray Irradiation on the Activity and Expression Levels of CYP1A2 and CYP2E1 in Rats. 2019 2
2 23339682 Assessment of effects of IR and IPC on activities of cytochrome P450 isozymes in rats by a five-drug cocktail approach. 2014 Feb 1
3 25073400 In vivo effects of scutellarin on the activities of CYP1A2, CYP2C11, CYP2D1, and CYP3A1/2 by cocktail probe drugs in rats. 2014 Jul 1
4 22695883 UPLC-MS-MS method for simultaneous determination of caffeine, tolbutamide, metoprolol, and dapsone in rat plasma and its application to cytochrome P450 activity study in rats. 2013 Jan 1
5 24555232 [In vivo evaluation of the metabolic ratio of CYP2C9 and CYP1A2 drug markers after administration of afobazole in comparison to standard inducers and inhibitors of cytochromes]. 2013 1
6 21796703 Effects of ephedra water decoction and cough tablets containing ephedra and liquorice on CYP1A2 and the pharmacokinetics of theophylline in rats. 2012 Mar 1
7 23167901 Caffeine induces CYP1A2 expression in rat hepatocytes but not in human hepatocytes. 2012 Jun 1 4
8 21468923 Effects of rutaecarpine on the metabolism and urinary excretion of caffeine in rats. 2011 Jan 2
9 19403289 Effects of major tanshinones isolated from Danshen (Salvia miltiorrhiza) on rat CYP1A2 expression and metabolism of model CYP1A2 probe substrates. 2009 Aug 1
10 18279840 Relative contribution of rat cytochrome P450 isoforms to the metabolism of caffeine: the pathway and concentration dependence. 2008 Apr 1 4
11 17652830 Effect of cytochrome P450 (CYP) inducers on caffeine metabolism in the rat. 2007 May-Jun 3
12 18195463 Caffeine metabolism during prolonged treatment of rats with antidepressant drugs. 2007 Nov-Dec 1
13 15598702 Black tea intake modulates the excretion of urinary mutagens in rats exposed to 6-aminochrysene: induction of cytochromes P450 by 6-aminochrysene in the rat. 2005 Jan 1
14 15822860 Effect of components of green tea extracts, caffeine and catechins on hepatic drug metabolizing enzyme activities and mutagenic transformation of carcinogens. 2005 Feb 1
15 16225762 Induction of liver cytochrome P450 1A2 expression by flutamide in rats. 2005 Nov 2
16 15027815 The role of cytochrome-P450 inhibitors in the prevention of hepatotoxicity after paracetamol overdose in rats. 2004 Jan 1
17 12706856 Mechanistic approach of contrasting modifying effects of caffeine on carcinogenesis in the rat colon and mammary gland induced with 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine. 2003 May 8 2
18 12738191 Induction of the procarcinogen-activating CYP1A2 by a herbal dietary supplement in rats and humans. 2003 Jun 1
19 14730100 Effects of classic and newer antidepressants on the oxidation pathways of caffeine in rat liver. In vitro study. 2003 Nov-Dec 2
20 14730101 Influence of classic and atypical neuroleptics on caffeine oxidation in rat liver microsomes. 2003 Nov-Dec 3
21 15619608 Application of the PKCYP test to predict caffeine clearance mediated by CYP1A2 in a rat acute liver injury model. 2003 4
22 11558565 Application of the PKCYP-test in cases of altered CYP1A2 for multiple CYP systems in rat models of disease. 2001 Sep 4
23 11697539 Effect of herbal teas on hepatic drug metabolizing enzymes in rats. 2001 Oct 1
24 11985335 Effects of phenothiazine neuroleptics on the rate of caffeine demethylation and hydroxylation in the rat liver. 2001 Nov-Dec 2
25 11990081 Effects of antidepressant drugs on the activity of cytochrome P-450 measured by caffeine oxidation in rat liver microsomes. 2001 Jul-Aug 3
26 10728918 Differential activities of CYP1A isozymes in hepatic and intestinal microsomes of control and 3-methylcholanthrene-induced rats. 2000 Feb 3
27 11038159 Decreased in vivo metabolism of drugs in chronic renal failure. 2000 Nov 2
28 10503909 Heterocyclic amine mixture carcinogenesis and its enhancement by caffeine in F344 rats. 1999 Sep 1 3
29 9630843 Involvement of CYP3A1, 2B1, and 2E1 in C-8 hydroxylation and CYP 1A2 and flavin-containing monooxygenase in N-demethylation of caffeine; identified by using inducer treated rat liver microsomes that are characterized with testosterone metabolic patterns. 1998 May 1 1
30 8723732 Caffeine induces cytochrome P4501A2: induction of CYP1A2 by tea in rats. 1996 May 4
31 8951351 Induction of liver and kidney CYP1A1/1A2 by caffeine in rat. 1996 Dec 24 1
32 7548239 Induction of hepatic CYP1A2 by the oral administration of caffeine to rats: lack of association with the Ah locus. 1995 Oct 17 4