Title : [In vivo evaluation of the metabolic ratio of CYP2C9 and CYP1A2 drug markers after administration of afobazole in comparison to standard inducers and inhibitors of cytochromes].

Pub. Date : 2013

PMID : 24555232






1 Functional Relationships(s)
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1 It is recommended to evaluate the activity of CYP1A2 by determining the MR for one of two caffeine metabolites, paraxanthine or theobromine, and the activity of CYP2C9 by determining the MR of metabolite Exp-3174 to losartan. Caffeine cytochrome P450, family 1, subfamily a, polypeptide 2 Rattus norvegicus