Pub. Date : 2001 Jul-Aug
PMID : 11990081
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | In the case of 1-N- and in particular 7-N-demethylation of caffeine, apart from CYP1A2, other cytochrome P-450 isoenzymes play a considerable role. | Caffeine | cytochrome P450, family 1, subfamily a, polypeptide 2 | Rattus norvegicus |
| 2 | The influence of amitriptyline on 8-hydroxylation and especially on 7-N-demethylation of caffeine was weaker (Ki = 108 and 190 pM, respectively) than on 3-N- or 1-N-demethylation, suggesting a narrower spectrum of cytochrome P-450 inhibition by amitriptyline than by imipramine, involving mainly the subfamily CYP1A2, and--to a lesser degree--CYP3A. | Caffeine | cytochrome P450, family 1, subfamily a, polypeptide 2 | Rattus norvegicus |
| 3 | However, fluoxetine displayed a clear inhibitory effect on caffeine 7-N-demethylation (Ki = 72 microM), the reaction which is catalyzed mainly by other than CYP1A2 isoenzymes. | Caffeine | cytochrome P450, family 1, subfamily a, polypeptide 2 | Rattus norvegicus |