Title : The role of cytochrome-P450 inhibitors in the prevention of hepatotoxicity after paracetamol overdose in rats.

Pub. Date : 2004 Jan

PMID : 15027815






1 Functional Relationships(s)
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1 Here, a mixture of ketoconazole, isoniazid and caffeine (inhibitor solution), known inhibitors of CYP3A, CYP2E1 and CYP1A2, was investigated for prevention of hepatotoxicity after paracetamol over-dose in rats. Caffeine cytochrome P450, family 1, subfamily a, polypeptide 2 Rattus norvegicus