Pub. Date : 1995 Oct 17
PMID : 7548239
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Induction of hepatic CYP1A2 by the oral administration of caffeine to rats: lack of association with the Ah locus. | Caffeine | cytochrome P450, family 1, subfamily a, polypeptide 2 | Rattus norvegicus |
| 2 | Immunoblot analysis revealed that caffeine gave rise to a dose-dependent increase in the hepatic CYP1A2, and at the highest dose only, CYP2B apoprotein levels. | Caffeine | cytochrome P450, family 1, subfamily a, polypeptide 2 | Rattus norvegicus |
| 3 | Molecular modelling revealed that the caffeine molecule could orientate itself within the putative CYP1A2 active site so as to facilitate demethylation of the N-1, N-3 and N-7 positions. | Caffeine | cytochrome P450, family 1, subfamily a, polypeptide 2 | Rattus norvegicus |
| 4 | In conclusion caffeine, being essentially planar, is an inducer of CYP1A2 in rat liver. | Caffeine | cytochrome P450, family 1, subfamily a, polypeptide 2 | Rattus norvegicus |