Guanosine Triphosphate

Rho/Rac guanine nucleotide exchange factor 2 ; Homo sapiens







53 Article(s)
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1 33762326 The Regulatory Subunit PPP2R2A of PP2A Enhances Th1 and Th17 Differentiation through Activation of the GEF-H1/RhoA/ROCK Signaling Pathway. 2021 Apr 15 1
2 30979377 NDR2 kinase contributes to cell invasion and cytokinesis defects induced by the inactivation of RASSF1A tumor-suppressor gene in lung cancer cells. 2019 Apr 12 1
3 29718126 Relapse pathway of glioblastoma revealed by single-cell molecular analysis. 2018 Jul 3 1
4 28706196 Synaptic GAP and GEF Complexes Cluster Proteins Essential for GTP Signaling. 2017 Jul 13 1
5 29106825 Recurrent De Novo Mutations Disturbing the GTP/GDP Binding Pocket of RAB11B Cause Intellectual Disability and a Distinctive Brain Phenotype. 2017 Nov 2 1
6 27458535 Modulation of B-cell receptor and microenvironment signaling by a guanine exchange factor in B-cell malignancies. 2016 Jun 1
7 27558716 Nanosecond Dynamics of Gαi1 Bound to Nucleotides or Ric-8A, a Gα Chaperone with GEF Activity. 2016 Aug 23 1
8 25707436 GTP-specific fab fragment-based GTPase activity assay. 2015 Mar 17 1
9 25825487 Combined rational design and a high throughput screening platform for identifying chemical inhibitors of a Ras-activating enzyme. 2015 May 15 1
10 26195453 A High-Throughput Assay for Rho Guanine Nucleotide Exchange Factors Based on the Transcreener GDP Assay. 2015 Dec 2
11 26304119 MYCBP2 Is a Guanosine Exchange Factor for Ran Protein and Determines Its Localization in Neurons of Dorsal Root Ganglia. 2015 Oct 16 1
12 26488653 Effect of the N-Terminal Helix and Nucleotide Loading on the Membrane and Effector Binding of Arl2/3. 2015 Oct 20 1
13 24597981 Amplification of B cell receptor-Erk signaling by Rasgrf-1 overexpression in chronic lymphocytic leukemia. 2014 Dec 2
14 24760397 A homogeneous quenching resonance energy transfer assay for the kinetic analysis of the GTPase nucleotide exchange reaction. 2014 Jul 2
15 22960035 Increased cell growth due to a new lipase-GEF (Phospholipase D2) fastly acting on Ras. 2013 Jan 2
16 22291991 RINL, guanine nucleotide exchange factor Rab5-subfamily, is involved in the EphA8-degradation pathway with odin. 2012 1
17 22673745 Divergence of Rho residue 43 impacts GEF activity. 2012 Jan-Mar 2
18 22825554 The R-Ras/RIN2/Rab5 complex controls endothelial cell adhesion and morphogenesis via active integrin endocytosis and Rac signaling. 2012 Oct 1
19 22847784 GEF-H1 over-expression in hepatocellular carcinoma promotes cell motility via activation of RhoA signalling. 2012 Dec 1
20 23076143 The many faces of the guanine-nucleotide exchange factor trio. 2012 Nov-Dec 1
21 21390270 Nucleotide binding switches the information flow in ras GTPases. 2011 Mar 3
22 21454697 Insulin-stimulated GLUT4 protein translocation in adipocytes requires the Rab10 guanine nucleotide exchange factor Dennd4C. 2011 May 13 2
23 21494904 Structural study of the Cdc25 domain from Ral-specific guanine-nucleotide exchange factor RalGPS1a. 2011 Apr 1
24 21586568 Characterization of RIN3 as a guanine nucleotide exchange factor for the Rab5 subfamily GTPase Rab31. 2011 Jul 8 1
25 21828055 Novel C-terminal motif within Sec7 domain of guanine nucleotide exchange factors regulates ADP-ribosylation factor (ARF) binding and activation. 2011 Oct 21 1
26 19356586 Characterisation of the nucleotide exchange factor ITSN1L: evidence for a kinetic discrimination of GEF-stimulated nucleotide release from Cdc42. 2009 Mar 27 3
27 19361519 Kinetic analysis of the guanine nucleotide exchange activity of TRAPP, a multimeric Ypt1p exchange factor. 2009 Jun 5 1
28 19745154 Activation of Rho GTPases by DOCK exchange factors is mediated by a nucleotide sensor. 2009 Sep 11 1
29 18347012 RanBP10 is a cytoplasmic guanine nucleotide exchange factor that modulates noncentrosomal microtubules. 2008 May 16 1
30 18505730 Dissociation of Rac1(GDP).RhoGDI complexes by the cooperative action of anionic liposomes containing phosphatidylinositol 3,4,5-trisphosphate, Rac guanine nucleotide exchange factor, and GTP. 2008 Aug 8 1
31 17488622 GEF-H1 modulates localized RhoA activation during cytokinesis under the control of mitotic kinases. 2007 May 2
32 17593019 Regulation of type V adenylate cyclase by Ric8a, a guanine nucleotide exchange factor. 2007 Sep 15 1
33 16257999 GEF-H1 is involved in agonist-induced human pulmonary endothelial barrier dysfunction. 2006 Mar 1
34 16472645 Purification and biochemical properties of Rac1, 2, 3 and the splice variant Rac1b. 2006 1
35 15709769 Mechanism of the guanine nucleotide exchange reaction of Ras GTPase--evidence for a GTP/GDP displacement model. 2005 Feb 22 3
36 15850775 Novel intermediate of Rac GTPase activation by guanine nucleotide exchange factor. 2005 Jun 3 6
37 16248653 Common semiopen conformations of Mg2+-free Ras, Rho, Rab, Arf, and Ran proteins combined with GDP and their similarity with GEF-bound forms. 2005 Nov 2 2
38 14597635 Mechanisms of guanine nucleotide exchange and Rac-mediated signaling revealed by a dominant negative trio mutant. 2004 Jan 30 1
39 14625275 Alternative splicing of Rac1 generates Rac1b, a self-activating GTPase. 2004 Feb 6 1
40 14712228 Homo- and hetero-oligomerization of PDZ-RhoGEF, LARG and p115RhoGEF by their C-terminal region regulates their in vivo Rho GEF activity and transforming potential. 2004 Jan 8 1
41 15544329 Oncogenic Dbl, Cdc42, and p21-activated kinase form a ternary signaling intermediate through the minimum interactive domains. 2004 Nov 23 3
42 12641750 Regulation of neuritogenesis and synaptic transmission by msec7-1, a guanine nucleotide exchange factor, in cultured Aplysia neurons. 2003 Apr 1
43 12680752 Rational design of genetically encoded fluorescence resonance energy transfer-based sensors of cellular Cdc42 signaling. 2003 Apr 15 1
44 11087745 Phospholipase Cdelta1 is a guanine nucleotide exchanging factor for transglutaminase II (Galpha h) and promotes alpha 1B-adrenoreceptor-mediated GTP binding and intracellular calcium release. 2001 Feb 23 2
45 9763446 Identification of regulators for Ypt1 GTPase nucleotide cycling. 1998 Oct 1
46 9790530 Structural basis for activation of ARF GTPase: mechanisms of guanine nucleotide exchange and GTP-myristoyl switching. 1998 Oct 16 1
47 8756332 Ras/Rap effector specificity determined by charge reversal. 1996 Aug 1
48 8589075 Small G proteins and the neutrophil NADPH oxidase. 1995 1
49 7581745 Translational control of eukaryotic gene expression. Role of the guanine nucleotide exchange factor and chain initiation factor-2. 1994-1995 2
50 8049218 Phosphorylation of the guanine nucleotide exchange factor and eukaryotic initiation factor 2 by casein kinase II regulates guanine nucleotide binding and GDP/GTP exchange. 1994 Aug 9 4