Title : Oncogenic Dbl, Cdc42, and p21-activated kinase form a ternary signaling intermediate through the minimum interactive domains.

Pub. Date : 2004 Nov 23

PMID : 15544329






3 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 The current biochemical model postulates that the GEF-stimulated GDP/GTP exchange of Rho GTPases leads to the active Rho-GTP species, and subsequently the active Rho GTPases interact with and activate the effectors. Guanosine Triphosphate Rho/Rac guanine nucleotide exchange factor 2 Homo sapiens
2 The current biochemical model postulates that the GEF-stimulated GDP/GTP exchange of Rho GTPases leads to the active Rho-GTP species, and subsequently the active Rho GTPases interact with and activate the effectors. Guanosine Triphosphate Rho/Rac guanine nucleotide exchange factor 2 Homo sapiens
3 Finally, PAK1, through the PDB domain, is able to accelerate the GEF-induced GTP loading onto Cdc42. Guanosine Triphosphate Rho/Rac guanine nucleotide exchange factor 2 Homo sapiens