Title : Phosphorylation of the guanine nucleotide exchange factor and eukaryotic initiation factor 2 by casein kinase II regulates guanine nucleotide binding and GDP/GTP exchange.

Pub. Date : 1994 Aug 9

PMID : 8049218






4 Functional Relationships(s)
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Protein Name
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1 In the presence of 1 mM Mg2+, the amount of GTP bound to dephosphorylated GEF is reduced 3.8-fold as compared to that of the CK-II-phosphorylated GEF. Guanosine Triphosphate Rho/Rac guanine nucleotide exchange factor 2 Homo sapiens
2 In the presence of 1 mM Mg2+, the amount of GTP bound to dephosphorylated GEF is reduced 3.8-fold as compared to that of the CK-II-phosphorylated GEF. Guanosine Triphosphate Rho/Rac guanine nucleotide exchange factor 2 Homo sapiens
3 Rephosphorylation with CK-II restores GTP binding and increases 4-5-fold the activity of GEF in the exchange of eIF-2-bound GDP for free GTP. Guanosine Triphosphate Rho/Rac guanine nucleotide exchange factor 2 Homo sapiens
4 The rate of GEF-catalyzed exchange of dephosphorylated eIF-2-bound GDP for GTP is approximately 2-fold slower than that with the isolated eIF-2. Guanosine Triphosphate Rho/Rac guanine nucleotide exchange factor 2 Homo sapiens