Title : Increased cell growth due to a new lipase-GEF (Phospholipase D2) fastly acting on Ras.

Pub. Date : 2013 Jan

PMID : 22960035






2 Functional Relationships(s)
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1 We report the novel finding that Phospholipase D2 (PLD2), through its PX and PH domains, binds specifically to Ras and catalyzes the GDP/GTP exchange (i.e., is a GEF), with potency comparable to Ras-GRF-1, a known Ras-GEF. Guanosine Triphosphate Rho/Rac guanine nucleotide exchange factor 2 Homo sapiens
2 We report the novel finding that Phospholipase D2 (PLD2), through its PX and PH domains, binds specifically to Ras and catalyzes the GDP/GTP exchange (i.e., is a GEF), with potency comparable to Ras-GRF-1, a known Ras-GEF. Guanosine Triphosphate Rho/Rac guanine nucleotide exchange factor 2 Homo sapiens