Title : Characterisation of the nucleotide exchange factor ITSN1L: evidence for a kinetic discrimination of GEF-stimulated nucleotide release from Cdc42.

Pub. Date : 2009 Mar 27

PMID : 19356586






3 Functional Relationships(s)
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1 We suggest a novel model for selective nucleotide exchange residing on a conformational change of Cdc42 upon binding of GTP, which enables effector binding to the Cdc42.GTP complex but, at the same time, excludes efficient modulation by the GEF. Guanosine Triphosphate Rho/Rac guanine nucleotide exchange factor 2 Homo sapiens
2 We suggest a novel model for selective nucleotide exchange residing on a conformational change of Cdc42 upon binding of GTP, which enables effector binding to the Cdc42.GTP complex but, at the same time, excludes efficient modulation by the GEF. Guanosine Triphosphate Rho/Rac guanine nucleotide exchange factor 2 Homo sapiens
3 The higher exchange activity of ITSN1L towards the GDP-bound conformation of Cdc42 could represent an evolutionary adaptation of this GEF that ensures nucleotide exchange towards the formation of the signalling-active GTP-bound form of Cdc42 and avoids dissociation of the active complex. Guanosine Triphosphate Rho/Rac guanine nucleotide exchange factor 2 Homo sapiens