| 1 |
35294066 | ArhGEF12 activates Rap1A and not RhoA in human dermal microvascular endothelial cells to reduce tumor necrosis factor-induced leak. | 2022 Apr |
1 |
| 2 |
35365657 | PI3Kγ stimulates a high molecular weight form of myosin light chain kinase to promote myeloid cell adhesion and tumor inflammation. | 2022 Apr 1 |
1 |
| 3 |
33872697 | Glucagon transiently stimulates mTORC1 by activation of an EPAC/Rap1 signaling axis. | 2021 Aug |
2 |
| 4 |
34603379 | Case Report: A Novel Missense Variant in the SIPA1L3 Gene Associated With Cataracts in a Chinese Family. | 2021 |
2 |
| 5 |
31879129 | Shank3 Binds to and Stabilizes the Active Form of Rap1 and HRas GTPases via Its NTD-ANK Tandem with Distinct Mechanisms. | 2020 Mar 3 |
4 |
| 6 |
32539601 | Large Extracellular Vesicle-Associated Rap1 Accumulates in Atherosclerotic Plaques, Correlates With Vascular Risks and Is Involved in Atherosclerosis. | 2020 Aug 28 |
1 |
| 7 |
32764635 | Dissection of α4β7 integrin regulation by Rap1 using novel conformation-specific monoclonal anti-β7 antibodies. | 2020 Aug 6 |
1 |
| 8 |
33391941 | Inherited Platelet Function Disorder From Novel Mutations in RAS Guanyl-Releasing Protein-2 Confirmed by Sanger Sequencing. | 2020 Nov 25 |
2 |
| 9 |
31545475 | Rap1A promotes esophageal squamous cell carcinoma metastasis through the AKT signaling pathway. | 2019 Nov |
2 |
| 10 |
29158262 | The EPAC-Rap1 pathway prevents and reverses cytokine-induced retinal vascular permeability. | 2018 Jan 12 |
2 |
| 11 |
29337043 | Membrane-permeable Rab27A is a regulator of the acrosome reaction: Role of geranylgeranylation and guanine nucleotides. | 2018 Apr |
2 |
| 12 |
26277896 | Extracellular calcium elicits feedforward regulation of the Toll-like receptor-triggered innate immune response. | 2017 Feb |
1 |
| 13 |
28740152 | A cell-based, quantitative and isoform-specific assay for exchange proteins directly activated by cAMP. | 2017 Jul 24 |
1 |
| 14 |
24704834 | Nuclear SIPA1 activates integrin β1 promoter and promotes invasion of breast cancer cells. | 2015 Mar 12 |
1 |
| 15 |
25856570 | RAP1 GTPase overexpression is associated with cervical intraepithelial neoplasia. | 2015 |
2 |
| 16 |
24287201 | The structure of Rap1 in complex with RIAM reveals specificity determinants and recruitment mechanism. | 2014 Apr |
1 |
| 17 |
24352565 | Identification of CalDAG-GEFI as an intracellular target for the vicinal dithiol binding agent phenylarsine oxide in human platelets. | 2014 May 5 |
1 |
| 18 |
24470025 | Pull-down assay for analysis of integrin-mediated activation of Rap proteins in adherent platelets. | 2014 |
1 |
| 19 |
25169936 | Platelets are highly activated in patients of chronic thromboembolic pulmonary hypertension. | 2014 Nov |
1 |
| 20 |
23652597 | Opposing HDAC4 nuclear fluxes due to phosphorylation by β-adrenergic activated protein kinase A or by activity or Epac activated CaMKII in skeletal muscle fibres. | 2013 Jul 15 |
1 |
| 21 |
23804711 | Chemokine unresponsiveness of chronic lymphocytic leukemia cells results from impaired endosomal recycling of Rap1 and is associated with a distinctive type of immunological anergy. | 2013 Aug 1 |
1 |
| 22 |
23946483 | Protein kinase A-dependent phosphorylation of Rap1 regulates its membrane localization and cell migration. | 2013 Sep 27 |
7 |
| 23 |
24349085 | Transglutaminase 2 contributes to apoptosis induction in Jurkat T cells by modulating Ca2+ homeostasis via cross-linking RAP1GDS1. | 2013 |
1 |
| 24 |
22614916 | Rap1GAP alters leukemia cell differentiation, apoptosis and invasion in vitro. | 2012 Aug |
1 |
| 25 |
23097489 | Radil controls neutrophil adhesion and motility through β2-integrin activation. | 2012 Dec |
1 |
| 26 |
21337364 | Cilostazol enhances integrin-dependent homing of progenitor cells by activation of cAMP-dependent protein kinase in synergy with Epac1. | 2011 May |
1 |
| 27 |
21750123 | Exchange protein directly activated by cAMP 1 (Epac1) is expressed in human neutrophils and mediates cAMP-dependent activation of the monomeric GTPase Rap1. | 2011 Oct |
1 |
| 28 |
20124489 | Downregulation of Rap1GAP through epigenetic silencing and loss of heterozygosity promotes invasion and progression of thyroid tumors. | 2010 Feb 15 |
2 |
| 29 |
20170508 | Retrotransposition and mutation events yield Rap1 GTPases with differential signalling capacity. | 2010 Feb 19 |
2 |
| 30 |
20413728 | Integrin-independent role of CalDAG-GEFI in neutrophil chemotaxis. | 2010 Aug |
1 |
| 31 |
20709748 | Splice variants of SmgGDS control small GTPase prenylation and membrane localization. | 2010 Nov 12 |
1 |
| 32 |
18784646 | C3G overexpression in glomerular epithelial cells during anti-GBM-induced glomerulonephritis. | 2009 Jan |
2 |
| 33 |
19086031 | Pyk2 mediates endothelin-1 signaling via p130Cas/BCAR3 cascade and regulates human glomerular mesangial cell adhesion and spreading. | 2009 Apr |
1 |
| 34 |
19433443 | The ability of GAP1IP4BP to function as a Rap1 GTPase-activating protein (GAP) requires its Ras GAP-related domain and an arginine finger rather than an asparagine thumb. | 2009 Jul |
1 |
| 35 |
19464664 | Prostaglandin E2 activates Rap1 via EP2/EP4 receptors and cAMP-signaling in rheumatoid synovial fibroblasts: involvement of Epac1 and PKA. | 2009 Jun |
2 |
| 36 |
19788733 | PKA and Epac cooperate to augment bradykinin-induced interleukin-8 release from human airway smooth muscle cells. | 2009 Sep 29 |
2 |
| 37 |
18922916 | Cell motility in chronic lymphocytic leukemia: defective Rap1 and alphaLbeta2 activation by chemokine. | 2008 Oct 15 |
1 |
| 38 |
17300802 | Insight into catalysis of a unique GTPase reaction by a combined biochemical and FTIR approach. | 2007 Apr 6 |
1 |
| 39 |
17517894 | IQGAP1 binds Rap1 and modulates its activity. | 2007 Jul 13 |
2 |
| 40 |
16170364 | Activation of Rac by cadherin through the c-Src-Rap1-phosphatidylinositol 3-kinase-Vav2 pathway. | 2006 Jan 5 |
2 |
| 41 |
16213650 | Identification and biochemical characterization of Rap2C, a new member of the Rap family of small GTP-binding proteins. | 2006 Mar-Apr |
1 |
| 42 |
16236484 | P2Y12 receptor signalling towards PKB proceeds through IGF-I receptor cross-talk and requires activation of Src, Pyk2 and Rap1. | 2006 Aug |
1 |
| 43 |
16436672 | Rap1GAP inhibits tumor growth in oropharyngeal squamous cell carcinoma. | 2006 Feb |
1 |
| 44 |
16507992 | Rap1-mediated activation of extracellular signal-regulated kinases by cyclic AMP is dependent on the mode of Rap1 activation. | 2006 Mar |
1 |
| 45 |
16757332 | Phospholipase Cepsilon guanine nucleotide exchange factor activity and activation of Rap1. | 2006 |
3 |
| 46 |
16757333 | Nore1 and RASSF1 regulation of cell proliferation and of the MST1/2 kinases. | 2006 |
1 |
| 47 |
16963453 | Nitric oxide produced in response to engagement of beta2 integrins on human neutrophils activates the monomeric GTPases Rap1 and Rap2 and promotes adhesion. | 2006 Nov 17 |
1 |
| 48 |
15613546 | Role of Rap1 in promoting sickle red blood cell adhesion to laminin via BCAM/LU. | 2005 Apr 15 |
1 |
| 49 |
16014623 | RA-RhoGAP, Rap-activated Rho GTPase-activating protein implicated in neurite outgrowth through Rho. | 2005 Sep 23 |
1 |
| 50 |
16172130 | Coordinate regulation of forskolin-induced cellular proliferation in macrophages by protein kinase A/cAMP-response element-binding protein (CREB) and Epac1-Rap1 signaling: effects of silencing CREB gene expression on Akt activation. | 2005 Nov 18 |
1 |