Title : Chemokine unresponsiveness of chronic lymphocytic leukemia cells results from impaired endosomal recycling of Rap1 and is associated with a distinctive type of immunological anergy.

Pub. Date : 2013 Aug 1

PMID : 23804711






1 Functional Relationships(s)
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1 Taken together, our findings indicate that chemokine unresponsiveness in CLL lymphocytes results from failure of Arf1/phospholipase D1-mediated translocation of Rap1 to the plasma membrane for GTP loading and may be a specific feature of anergy induced by DNA Ags. Guanosine Triphosphate RAP1A, member of RAS oncogene family Homo sapiens