Title : P2Y12 receptor signalling towards PKB proceeds through IGF-I receptor cross-talk and requires activation of Src, Pyk2 and Rap1.

Pub. Date : 2006 Aug

PMID : 16236484






1 Functional Relationships(s)
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1 In conclusion, the data reveal a novel type of cross-talk between P2Y12 and IGF-I receptors that proceeds through Gbetagamma-, Ca2+-and PLD2-dependent activation of the Pyk2/Src pathway resulting in GTP-loading of Rap1 required for an increased PKB phosphorylation. Guanosine Triphosphate RAP1A, member of RAS oncogene family Homo sapiens