Guanosine Triphosphate

paired like homeodomain 2 ; Homo sapiens







62 Article(s)
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1 33347886 Allosteric Pathways Originating at Cysteine Residues in Regulators of G-Protein Signaling Proteins. 2021 Feb 2 1
2 29460621 Differential Protein Dynamics of Regulators of G-Protein Signaling: Role in Specificity of Small-Molecule Inhibitors. 2018 Mar 7 2
3 28098342 The evolution of regulators of G protein signalling proteins as drug targets - 20 years in the making: IUPHAR Review 21. 2017 Mar 1
4 26755720 Structure of the Regulator of G Protein Signaling 8 (RGS8)-Gαq Complex: MOLECULAR BASIS FOR Gα SELECTIVITY. 2016 Mar 4 3
5 26829215 Regulator of G protein signaling 8 inhibits protease-activated receptor 1/Gi/o signaling by forming a distinct G protein-dependent complex in live cells. 2016 May 2
6 26008785 Regulators of G-protein-signaling proteins: negative modulators of G-protein-coupled receptor signaling. 2015 1
7 24560274 Double suppression of the Gα protein activity by RGS proteins. 2014 Feb 20 2
8 23295489 Crystallization and preliminary X-ray diffraction studies of Drosophila melanogaster Gαo-subunit of heterotrimeric G protein in complex with the RGS domain of CG5036. 2013 Jan 1 1
9 23626793 A high throughput screen for RGS proteins using steady state monitoring of free phosphate formation. 2013 2
10 23637832 Regulator of G-protein signaling - 5 (RGS5) is a novel repressor of hedgehog signaling. 2013 1
11 23804514 Association of Rgs7/Gβ5 complexes with Girk channels and GABAB receptors in hippocampal CA1 pyramidal neurons. 2013 Dec 2
12 24041654 Reversible inhibitors of regulators of G-protein signaling identified in a high-throughput cell-based calcium signaling assay. 2013 Dec 1
13 24093330 Conformational dynamics of a regulator of G-protein signaling protein reveals a mechanism of allosteric inhibition by a small molecule. 2013 Dec 20 1
14 22382998 Evaluating modulators of "Regulator of G-protein Signaling" (RGS) proteins. 2012 Mar 3
15 22899066 The RGS proteins add to the diversity of soybean heterotrimeric G-protein signaling. 2012 Sep 1 1
16 23161137 Chaperone-mediated assembly of G protein complexes. 2012 1
17 23292690 Structure based energy calculation to determine the regulation of G protein signalling by RGS and RGS-G protein interaction specificity. 2012 Sep 1
18 21064165 Modulation of a GEF switch: autoinhibition of the intrinsic guanine nucleotide exchange activity of p115-RhoGEF. 2011 Jan 1
19 20530129 Allosteric inhibition of the regulator of G protein signaling-Galpha protein-protein interaction by CCG-4986. 2010 Sep 1
20 20573995 RNA interference screen for RGS protein specificity at muscarinic and protease-activated receptors reveals bidirectional modulation of signaling. 2010 Sep 1
21 19212142 Structural determinants involved in the formation and activation of G protein betagamma dimers. 2009 1
22 20374714 Structure and function of regulator of G protein signaling homology domains. 2009 2
23 18434540 Molecular architecture of Galphao and the structural basis for RGS16-mediated deactivation. 2008 Apr 29 2
24 18434541 Structural diversity in the RGS domain and its interaction with heterotrimeric G protein alpha-subunits. 2008 Apr 29 8
25 18523757 Functional reconstitution of the human chemokine receptor CXCR4 with G(i)/G (o)-proteins in Sf9 insect cells. 2008 Sep 1
26 19175184 Regulation of LH receptor and PGF2alpha receptor signaling by the regulator of G protein signaling 2 (RGS2) in human and mouse granulosa cells. 2008 Oct 31 2
27 17576169 RGS18 acts as a negative regulator of osteoclastogenesis by modulating the acid-sensing OGR1/NFAT signaling pathway. 2007 Oct 1
28 17660054 The RGS protein inhibitor CCG-4986 is a covalent modifier of the RGS4 Galpha-interaction face. 2007 Sep 1
29 16246175 Biochemical characterization of RGS14: RGS14 activity towards G-protein alpha subunits is independent of its binding to Rap2A. 2006 Feb 15 1
30 16627589 RGS2 is regulated by angiotensin II and functions as a negative feedback of aldosterone production in H295R human adrenocortical cells. 2006 Aug 2
31 15324308 Phosphatidylinositol 3,4,5-trisphosphate and Ca2+/calmodulin competitively bind to the regulators of G-protein-signalling (RGS) domain of RGS4 and reciprocally regulate its action. 2005 Jan 1 2
32 15840508 A direct fluorescence-based assay for RGS domain GTPase accelerating activity. 2005 May 15 1
33 16246308 In vivo interaction between RGS4 and calmodulin visualized with FRET techniques: possible involvement of lipid raft. 2005 Dec 16 1
34 12923211 Cell signal control of the G protein-gated potassium channel and its subcellular localization. 2004 Jan 15 1
35 15313558 Role of palmitoylation in RGS protein function. 2004 1
36 15313562 Assays of RGS protein modulation by phosphatidylinositides and calmodulin. 2004 1
37 15488183 Modular architecture and novel protein-protein interactions regulating the RGS-containing Rho guanine nucleotide exchange factors. 2004 1
38 12446706 A spatial focusing model for G protein signals. Regulator of G protein signaling (RGS) protien-mediated kinetic scaffolding. 2003 Feb 28 2
39 12753087 Concerted stimulation and deactivation of pertussis toxin-sensitive G proteins by chimeric G protein-coupled receptor-regulator of G protein signaling 4 fusion proteins: analysis of the contribution of palmitoylated cysteine residues to the GAP activity of RGS4. 2003 Jun 1
40 12885252 Differential interaction of GRK2 with members of the G alpha q family. 2003 Aug 5 2
41 11771419 Assay of RGS protein activity in vitro using purified components. 2002 1
42 11904384 PIP3 inhibition of RGS protein and its reversal by Ca2+/calmodulin mediate voltage-dependent control of the G protein cycle in a cardiac K+ channel. 2002 Apr 2 2
43 11008492 RGS proteins: lessons from the RGS9 subfamily. 2001 1
44 11495924 RGS9-G beta 5 substrate selectivity in photoreceptors. Opposing effects of constituent domains yield high affinity of RGS interaction with the G protein-effector complex. 2001 Oct 5 1
45 11520900 Differential capacities of the RGS1, RGS16 and RGS-GAIP regulators of G protein signaling to enhance alpha2A-adrenoreceptor agonist-stimulated GTPase activity of G(o1)alpha. 2001 Aug 1
46 11604548 Bridging with GAPs: receptor communication through RGS proteins. 2001 Oct 16 3
47 11729322 RGS-PX1, a GAP for GalphaS and sorting nexin in vesicular trafficking. 2001 Nov 30 1
48 10677488 A regulator of G protein signaling interaction surface linked to effector specificity. 2000 Feb 15 5
49 10852703 NMR structure of free RGS4 reveals an induced conformational change upon binding Galpha. 2000 Jun 20 1
50 10936173 Activation of extracellular signal-regulated kinase (ERK) and Akt by human serotonin 5-HT(1B) receptors in transfected BE(2)-C neuroblastoma cells is inhibited by RGS4. 2000 Sep 1