2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one

mitogen activated protein kinase kinase 1 ; Rattus norvegicus







174 Article(s)
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1 34116563 Inhibition of the Ras/ERK1/2 pathway contributes to the protective effect of ginsenoside Re against intimal hyperplasia. 2021 Aug 2 1
2 34647720 Extracellular-Signal-Regulated Kinase Inhibition Switches APP Processing from β- to α-Secretase under Oxidative Stress: Modulation of ADAM10 by SIRT1/NF-κB Signaling. 2021 Nov 3 2
3 31562895 Differential effects of MEK inhibitors on rat neural stem cell differentiation: Repressive roles of MEK2 in neurogenesis and induction of astrocytogenesis by PD98059. 2019 Nov 1
4 28323089 Enhancement of ERK phosphorylation and photic responses in Vc/C1 neurons of a migraine model. 2017 Apr 24 1
5 28392425 T-cadherin promotes autophagy and survival in vascular smooth muscle cells through MEK1/2/Erk1/2 axis activation. 2017 Jul 1
6 24634418 Electromagnetic fields promote osteogenesis of rat mesenchymal stem cells through the PKA and ERK1/2 pathways. 2016 Oct 1
7 26750148 Contribution of adrenomedullin to the switch of G protein-coupled μ-opioid receptors from Gi to Gs in the spinal dorsal horn following chronic morphine exposure in rats. 2016 Apr 1
8 27118769 ERK-GluR1 phosphorylation in trigeminal spinal subnucleus caudalis neurons is involved in pain associated with dry tongue. 2016 1
9 27302964 Insulin as a Potent Stimulator of Akt, ERK and Inhibin-βE Signaling in Osteoblast-Like UMR-106 Cells. 2016 Nov 1 1
10 27592458 Homocysteine regulates endothelin type B receptors in vascular smooth muscle cells. 2016 Dec 1
11 25421413 Role of group I metabotropic glutamate receptors, mGluR1/mGluR5, in connexin43 phosphorylation and inhibition of gap junctional intercellular communication in H9c2 cardiomyoblast cells. 2015 Feb 1
12 25495055 Pyroglutamic acid stimulates DNA synthesis in rat primary hepatocytes through the mitogen-activated protein kinase pathway. 2015 1
13 25792236 Activation of extracellular signal-regulated protein kinases 1 and 2 (ERK1/2) by free fatty acid receptor 1 (FFAR1/GPR40) protects from palmitate-induced beta cell death, but plays no role in insulin secretion. 2015 1
14 26065826 MAPK signaling downstream to TLR4 contributes to paclitaxel-induced peripheral neuropathy. 2015 Oct 1
15 26426693 PD98059 Influences Immune Factors and Enhances Opioid Analgesia in Model of Neuropathy. 2015 1
16 26459015 Effects of Forskolin on Trefoil factor 1 expression in cultured ventral mesencephalic dopaminergic neurons. 2015 Dec 3 1
17 24315856 Low density lipoprotein induces upregulation of vasoconstrictive endothelin type B receptor expression. 2014 Jan 1
18 24401988 Stress-induced stimulation of choline transport in cultured choroid plexus epithelium exposed to low concentrations of cadmium. 2014 Mar 1 1
19 25048018 Inhibition of smooth muscle cell proliferation by ezetimibe via the cyclin D1-MAPK pathway. 2014 2
20 25279551 Involvement of trigeminal transition zone and laminated subnucleus caudalis in masseter muscle hypersensitivity associated with tooth inflammation. 2014 1
21 25305575 Sigma-1 receptor stimulation protects retinal ganglion cells from ischemia-like insult through the activation of extracellular-signal-regulated kinases 1/2. 2014 Nov 1
22 23451198 Involvement of ERK phosphorylation of trigeminal spinal subnucleus caudalis neurons in thermal hypersensitivity in rats with infraorbital nerve injury. 2013 1
23 23663343 [Role of MEK1/ERK1, 2 pathways in the calcium-sensing receptor mediation of hypoxia-induced proliferation of rat pulmonary artery smooth muscle cells]. 2013 Feb 26 1
24 23686980 Neuroprotection of ischemic postconditioning by downregulating the postsynaptic signaling mediated by kainate receptors. 2013 Jul 1
25 23708402 Reactive oxygen species and extracellular signal-regulated kinase 1/2 mediate hexachlorobenzene-induced cell death in FRTL-5 rat thyroid cells. 2013 Aug 1
26 24040163 Hypoxia-inducible factor-1alpha and MAPK co-regulate activation of hepatic stellate cells upon hypoxia stimulation. 2013 1
27 22285838 High glucose enhances TGF-β1 expression in rat bone marrow stem cells via ERK1/2-mediated inhibition of STAT3 signaling. 2012 Apr 9 1
28 22575563 Involvement of phosphatidylinositol 3-kinase/Akt on basic fibroblast growth factor-induced glial cell line-derived neurotrophic factor release from rat glioma cells. 2012 Jun 29 1
29 22644739 Transmural pressure loading enhances gastric mucosal cell proliferation. 2012 Oct 1
30 22797318 GIT1Y321 phosphorylation is required for ERK1/2- and PDGF-dependent VEGF secretion from osteoblasts to promote angiogenesis and bone healing. 2012 Oct 1
31 20937724 Manganese induces tau hyperphosphorylation through the activation of ERK MAPK pathway in PC12 cells. 2011 Jan 2
32 21073657 The calcium-sensing receptor mediates hypoxia-induced proliferation of rat pulmonary artery smooth muscle cells through MEK1/ERK1,2 and PI3K pathways. 2011 Mar 1
33 21371423 Megalin is downregulated via LPS-TNF-α-ERK1/2 signaling pathway in proximal tubule cells. 2011 Apr 1 1
34 21586513 Prevention of carcinogenesis and inhibition of breast cancer tumor burden by dietary stearate. 2011 Aug 1
35 21599960 Monosodium iodoacetate-induced joint pain is associated with increased phosphorylation of mitogen activated protein kinases in the rat spinal cord. 2011 May 20 1
36 21907330 Organization of pERK-immunoreactive cells in trigeminal spinal nucleus caudalis, upper cervical cord, NTS and Pa5 following capsaicin injection into masticatory and swallowing-related muscles in rats. 2011 Oct 12 1
37 21952000 Involvement of peripheral ionotropic glutamate receptors in orofacial thermal hyperalgesia in rats. 2011 Sep 28 1
38 20074614 Close association of p38 and JNK with plasminogen-dependent upregulation of PAI-1 in rat astrocytes in vitro. 2010 Mar 3 1
39 20378856 Cyclic mechanical stretch induces cardiomyocyte orientation and polarization of the gap junction protein connexin43. 2010 May 28 1
40 20401736 Phenotypic modulation of cultured vascular smooth muscle cells: a functional analysis focusing on MLC and ERK1/2 phosphorylation. 2010 Aug 1
41 20580365 Leukotriene B4 mediates vascular smooth muscle cell migration through αvβ3 integrin transactivation. 2010 Oct 1
42 20591183 Inhibition of gap junctional Intercellular communication in WB-F344 rat liver epithelial cells by triphenyltin chloride through MAPK and PI3-kinase pathways. 2010 Jun 30 1
43 20658965 Cell cycle events mediate lactacystin-induced apoptotic death of neuronal PC12 cells. 2010 Dec 1
44 20735995 Manganese induces the overexpression of α-synuclein in PC12 cells via ERK activation. 2010 Nov 4 1
45 20809049 Phosphorylation of extracellular signal-regulated kinase (ERK)-1/2 Is associated with the downregulation of peroxisome proliferator-activated receptor (PPAR)-γ during polymicrobial sepsis. 2010 Nov-Dec 1
46 19469685 Axonal outgrowth and Erk1/2 activation by training after spinal cord injury in rats. 2009 Nov 1
47 19881297 Sevoflurane postconditioning protects chronically-infarcted rat hearts against ischemia-reperfusion injury by activation of pro-survival kinases and inhibition of mitochondrial permeability transition pore opening upon reperfusion. 2009 Nov 1
48 18041768 FGF-1-induced matrix metalloproteinase-9 expression in breast cancer cells is mediated by increased activities of NF-kappaB and activating protein-1. 2008 Jun 1
49 18202115 Interleukin-11 antagonizes Fas ligand-mediated apoptosis in IEC-18 intestinal epithelial crypt cells: role of MEK and Akt-dependent signaling. 2008 Mar 1
50 18223161 T3 increases Na-K-ATPase activity via a MAPK/ERK1/2-dependent pathway in rat adult alveolar epithelial cells. 2008 Apr 1