Title : [Role of MEK1/ERK1, 2 pathways in the calcium-sensing receptor mediation of hypoxia-induced proliferation of rat pulmonary artery smooth muscle cells].

Pub. Date : 2013 Feb 26

PMID : 23663343






1 Functional Relationships(s)
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1 PD98059 (a MEK1 inhibitor) decreased the up-regulation of PCNA expression, BrdU incorporation and the increase of cell proliferation index induced by hypoxia and GdCl3 in PASMCs (0.441 +- 0.020, 0.71 +- 0.07, 0.72 +- 0.06, 115.5 +- 4.0, 9.3 +- 1.1, all P < 0.05). 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one mitogen activated protein kinase kinase 1 Rattus norvegicus