Title : Contribution of adrenomedullin to the switch of G protein-coupled μ-opioid receptors from Gi to Gs in the spinal dorsal horn following chronic morphine exposure in rats.

Pub. Date : 2016 Apr

PMID : 26750148






1 Functional Relationships(s)
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1 Co-administration of the PKA inhibitor H-89 (5 mug) or MEK1 inhibitor PD98059 (1 mug) reversed the AM-induced thermal/mechanical hypersensitivity, decline in morphine analgesic potency, switch of G protein-coupled mu receptor and increase in cAMP. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one mitogen activated protein kinase kinase 1 Rattus norvegicus