Tyrosine

interleukin 6 ; Homo sapiens







169 Article(s)
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51 19201396 Macrophage-derived interleukin-6 up-regulates MUC1, but down-regulates MUC2 expression in the human colon cancer HT-29 cell line. 2009 4
52 19274102 Chemical probes that competitively and selectively inhibit Stat3 activation. 2009 1
53 18204781 Phosphorylation and nuclear translocation of STAT3 regulated by the Epstein-Barr virus latent membrane protein 1 in nasopharyngeal carcinoma. 2008 Feb 1
54 18503751 An RNA biding protein, Y14 interacts with and modulates STAT3 activation. 2008 Aug 1 1
55 18544087 Cantharidin induces apoptosis of human multiple myeloma cells via inhibition of the JAK/STAT pathway. 2008 Sep 1
56 18593565 Caspase-mediated cleavage of the signal-transducing IL-6 receptor subunit gp130. 2008 Sep 15 2
57 19967068 Tyrphostin ErbB2 Inhibitors AG825 and AG879 Have Non-specific Suppressive Effects on gp130/ STAT3 Signaling. 2008 Oct 1
58 17242212 Interleukin-6 impairs the insulin signaling pathway, promoting production of nitric oxide in human umbilical vein endothelial cells. 2007 Mar 1
59 17510282 Unphosphorylated STAT3 accumulates in response to IL-6 and activates transcription by binding to NFkappaB. 2007 Jun 1 2
60 17531096 Stat3 is tyrosine-phosphorylated through the interleukin-6/glycoprotein 130/Janus kinase pathway in breast cancer. 2007 1
61 17716862 Preformed STAT3 transducer complexes in human HepG2 cells and rat hepatocytes. 2007 Nov 3
62 17823310 HGAL, a lymphoma prognostic biomarker, interacts with the cytoskeleton and mediates the effects of IL-6 on cell migration. 2007 Dec 15 1
63 17956865 The functional role of an interleukin 6-inducible CDK9.STAT3 complex in human gamma-fibrinogen gene expression. 2007 Dec 21 1
64 16407171 Membrane-associated STAT3 and PY-STAT3 in the cytoplasm. 2006 Mar 17 1
65 16926159 Pyrrolidine dithiocarbamate inhibits interleukin-6 signaling through impaired STAT3 activation and association with transcriptional coactivators in hepatocytes. 2006 Oct 20 1
66 17258468 STAT1 and STAT3 phosphorylation by porins are independent of JAKs but are dependent on MAPK pathway and plays a role in U937 cells production of interleukin-6. 2006 Dec 1
67 15665187 Induction of human sperm capacitation and protein tyrosine phosphorylation by endometrial cells and interleukin-6. 2005 Feb 1
68 15894558 IL-6 induces neuroendocrine dedifferentiation and cell proliferation in non-small cell lung cancer cells. 2005 Sep 1
69 16086584 Binding of madindoline A to the extracellular domain of gp130. 2005 Aug 16 1
70 12974672 Analysis of Stat3 (signal transducer and activator of transcription 3) dimerization by fluorescence resonance energy transfer in living cells. 2004 Jan 15 3
71 14676217 High glucose enhances interleukin-6-induced vascular endothelial growth factor 165 expression via activation of gp130-mediated p44/42 MAPK-CCAAT/enhancer binding protein signaling in gingival fibroblasts. 2004 Feb 20 1
72 14979481 The protein tyrosine phosphatase CD45 is required for interleukin 6 signaling in U266 myeloma cells. 2004 Jan 1
73 14981536 Synergism of cytoplasmic kinases in IL6-induced ligand-independent activation of androgen receptor in prostate cancer cells. 2004 Mar 11 1
74 15010462 Critical role for hematopoietic cell kinase (Hck)-mediated phosphorylation of Gab1 and Gab2 docking proteins in interleukin 6-induced proliferation and survival of multiple myeloma cells. 2004 May 14 1
75 15284182 IL-6-induced survival of colorectal carcinoma cells is inhibited by butyrate through down-regulation of the IL-6 receptor. 2004 Nov 1
76 15313471 Differential expression and effects of gp130 cytokines and receptors in prostate cancer cells. 2004 Nov 1
77 15591791 Vanadate stimulates monocytic differentiation activity of IL-6 by enhancing actin filament polymerization in HL-60 cells. 2004 Nov-Dec 1
78 12403768 SHP2 and SOCS3 contribute to Tyr-759-dependent attenuation of interleukin-6 signaling through gp130. 2003 Jan 3 3
79 12595539 JAK2/STAT3, not ERK1/2, mediates interleukin-6-induced activation of inducible nitric-oxide synthase and decrease in contractility of adult ventricular myocytes. 2003 May 2 2
80 12626585 Activation of STAT3 by IL-6 and IL-10 in primary human macrophages is differentially modulated by suppressor of cytokine signaling 3. 2003 Mar 15 1
81 12710894 Reduction of serum C-reactive protein by statin therapy may reflect decreased isoprenylation of Rac-1, a mediator of the IL-6 signal transduction pathway. 2003 May 1
82 12847270 Inhibition of IFN-gamma-mediated inducible nitric oxide synthase induction by the peroxisome proliferator-activated receptor gamma agonist, 15-deoxy-delta 12,14-prostaglandin J2, involves inhibition of the upstream Janus kinase/STAT1 signaling pathway. 2003 Jul 15 1
83 12952969 Interleukin-6 (IL-6) induces insulin resistance in 3T3-L1 adipocytes and is, like IL-8 and tumor necrosis factor-alpha, overexpressed in human fat cells from insulin-resistant subjects. 2003 Nov 14 1
84 14500551 TGF-beta down-regulates IL-6 signaling in intestinal epithelial cells: critical role of SMAD-2. 2003 Nov 3
85 11788581 Function and molecular modeling of the interaction between human interleukin 6 and its HNK-1 oligosaccharide ligands. 2002 Apr 5 1
86 11815625 Cytokine signaling: STATS in plasma membrane rafts. 2002 Apr 5 1
87 11849447 STAT3, but not ERKs, mediates the IL-6-induced proliferation of renal cancer cells, ACHN and 769P. 2002 Mar 2
88 11884403 Shedding of the interleukin-6 (IL-6) receptor (gp80) determines the ability of IL-6 to induce gp130 phosphorylation in human osteoblasts. 2002 May 10 2
89 11960349 Downregulation of IL-6-induced STAT3 tyrosine phosphorylation by TGF-beta1 is mediated by caspase-dependent and -independent processes. 2002 Apr 4
90 12119038 SH2 domains from suppressor of cytokine signaling-3 and protein tyrosine phosphatase SHP-2 have similar binding specificities. 2002 Jul 23 1
91 12235142 Interactions of STAT3 with caveolin-1 and heat shock protein 90 in plasma membrane raft and cytosolic complexes. Preservation of cytokine signaling during fever. 2002 Nov 22 2
92 12359225 The nuclear isoform of protein-tyrosine phosphatase TC-PTP regulates interleukin-6-mediated signaling pathway through STAT3 dephosphorylation. 2002 Oct 4 1
93 12360405 IL-6 mediated activation of STAT3 bypasses Janus kinases in terminally differentiated B lineage cells. 2002 Oct 3 1
94 12453891 Interleukin-6 induces cellular insulin resistance in hepatocytes. 2002 Dec 1
95 11154231 Bone morphogenetic protein-4 inhibits proliferation and induces apoptosis of multiple myeloma cells. 2001 Jan 15 1
96 11196191 Interleukin 6 inhibits proliferation and, in cooperation with an epidermal growth factor receptor autocrine loop, increases migration of T47D breast cancer cells. 2001 Jan 1 2
97 11270639 Interleukin-6 up-regulates the oxytocin receptor in cultured uterine smooth muscle cells. 2001 Mar 1
98 11335711 Sequential activation of Rac-1, SEK-1/MKK-4, and protein kinase Cdelta is required for interleukin-6-induced STAT3 Ser-727 phosphorylation and transactivation. 2001 Jul 20 2
99 11337018 STAT3 exerts two-way regulation in the biological effects of IL-6 in M1 leukemia cells. 2001 Jun 2
100 11429693 The YXXQ motif in gp 130 is crucial for STAT3 phosphorylation at Ser727 through an H7-sensitive kinase pathway. 2001 Jun 14 1